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Hematology Reports
Volume 7
Issue 3
10.4081/hr.2015.5906
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

B-Cell-Rich T-Cell Lymphoma Associated with Epstein-Barr Virus-Reactivation and T-Cell Suppression Following Antithymocyte Globulin Therapy in a Patient with Severe Aplastic Anemia

by
Nobuyoshi Hanaoka
1,*,
Shogo Murata
1,
Hiroki Hosoi
1,
Aiko Shimokado
2,
Toshiki Mushino
1,
Kodai Kuriyama
1,
Kazuo Hatanaka
1,
Akinori Nishikawa
1,
Miwa Kurimoto
1,
Takashi Sonoki
1,
Yasuteru Muragaki
2 and
Hideki Nakakuma
1
1
Department of Hematology/Oncology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan
2
First Department of Pathology, Wakayama Medical University, Wakayama 641-8510, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(3), 5906; https://doi.org/10.4081/hr.2015.5906
Submission received: 18 March 2015 / Revised: 10 July 2015 / Accepted: 2 September 2015 / Published: 23 September 2015

Abstract

B-cell lymphoproliferative disorder (B-LPD) is generally characterized by the proliferation of Epstein-Barr virus (EBV-infected B lymphocytes. We here report the development of EBV-negative B-LPD associated with EBV-reactivation following antithymocyte globulin (ATG) therapy in a patient with aplastic anemia. The molecular autopsy study showed the sparse EBV-infected clonal T cells could be critically involved in the pathogenesis of EBV-negative oligoclonal B-LPD through cytokine amplification and escape from T-cell surveillances attributable to ATG-based immunosuppressive therapy, leading to an extremely rare B-cell-rich T-cell lymphoma. This report helps in elucidating the complex pathophysiology of intractable B-LPD refractory to rituximab.
Keywords: lymphoproliferative disorder; Epstein-Barr virus; molecular autopsy; anti-thymocyte globulin; aplastic anemia lymphoproliferative disorder; Epstein-Barr virus; molecular autopsy; anti-thymocyte globulin; aplastic anemia

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MDPI and ACS Style

Hanaoka, N.; Murata, S.; Hosoi, H.; Shimokado, A.; Mushino, T.; Kuriyama, K.; Hatanaka, K.; Nishikawa, A.; Kurimoto, M.; Sonoki, T.; et al. B-Cell-Rich T-Cell Lymphoma Associated with Epstein-Barr Virus-Reactivation and T-Cell Suppression Following Antithymocyte Globulin Therapy in a Patient with Severe Aplastic Anemia. Hematol. Rep. 2015, 7, 5906. https://doi.org/10.4081/hr.2015.5906

AMA Style

Hanaoka N, Murata S, Hosoi H, Shimokado A, Mushino T, Kuriyama K, Hatanaka K, Nishikawa A, Kurimoto M, Sonoki T, et al. B-Cell-Rich T-Cell Lymphoma Associated with Epstein-Barr Virus-Reactivation and T-Cell Suppression Following Antithymocyte Globulin Therapy in a Patient with Severe Aplastic Anemia. Hematology Reports. 2015; 7(3):5906. https://doi.org/10.4081/hr.2015.5906

Chicago/Turabian Style

Hanaoka, Nobuyoshi, Shogo Murata, Hiroki Hosoi, Aiko Shimokado, Toshiki Mushino, Kodai Kuriyama, Kazuo Hatanaka, Akinori Nishikawa, Miwa Kurimoto, Takashi Sonoki, and et al. 2015. "B-Cell-Rich T-Cell Lymphoma Associated with Epstein-Barr Virus-Reactivation and T-Cell Suppression Following Antithymocyte Globulin Therapy in a Patient with Severe Aplastic Anemia" Hematology Reports 7, no. 3: 5906. https://doi.org/10.4081/hr.2015.5906

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