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Hematology Reports
Volume 9
Issue 4
10.4081/hr.2017.7437
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Case Report

A Rare Case of De Novo CD5+ Diffuse Large B-Cell Lymphoma in Leukemic Phase and Positive for CD13

by
Giovanni Carulli
1,2,*,
Eugenio Mario Ciancia
3,
Francesco Caracciolo
1,
Paola Sammuri
1,
Cristiana Domenichini
1,
Maria Immacolata Ferreri
4,
Alessia Di Vita
1,
Virginia Ottaviano
1,
Martina Rousseau
1 and
Mario Petrini
1
1
Division of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
2
Division of Hematology, Santa Chiara Hospital, Via Roma 67, 56126 Pisa, Italy
3
Second Division of Pathology, AOUP, 56126 Pisa, Italy
4
Laboratory of Medical Genetics, AOUP, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2017, 9(4), 7437; https://doi.org/10.4081/hr.2017.7437
Submission received: 10 October 2017 / Revised: 17 November 2017 / Accepted: 1 December 2017 / Published: 3 January 2018

Abstract

We report a case of de novo diffuse large B-cell lymphoma (DLBCL) in leukemic phase, positive for both CD5 and CD13. Morphologic evaluation, flow cytometric immunophenotyping, karyotyping and polymerase chain reaction studies were performed. Neoplastic lymphocytes appeared as blast-like cells, positive for CD19, CD20, CD5, CD13, CD79a, HLADR, and with restriction for surface immunoglobulin K light chains. Rearrangement of IgH gene, BCL2/IgH translocation and complex karyotype were found. The patient was treated with RCOMP regimen and achieved complete remission. However, only one month after the first restaging of disease, the patient presented with symptoms attributable to central nervous system involvement and her clinical conditions worsened rapidly. While both CD5 expression and leukemic presentation are uncommon findings in DLBCL, positivity for CD13 is very rare. The outcome of our patient shows the poor prognosis of CD5+ DLBCL with leukemic presentation. The possible role of CD13 coexpression is discussed.
Keywords: CD5; CD13; diffuse large B-cell lymphoma; DLBCL; flow cytometry CD5; CD13; diffuse large B-cell lymphoma; DLBCL; flow cytometry

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MDPI and ACS Style

Carulli, G.; Ciancia, E.M.; Caracciolo, F.; Sammuri, P.; Domenichini, C.; Ferreri, M.I.; Di Vita, A.; Ottaviano, V.; Rousseau, M.; Petrini, M. A Rare Case of De Novo CD5+ Diffuse Large B-Cell Lymphoma in Leukemic Phase and Positive for CD13. Hematol. Rep. 2017, 9, 7437. https://doi.org/10.4081/hr.2017.7437

AMA Style

Carulli G, Ciancia EM, Caracciolo F, Sammuri P, Domenichini C, Ferreri MI, Di Vita A, Ottaviano V, Rousseau M, Petrini M. A Rare Case of De Novo CD5+ Diffuse Large B-Cell Lymphoma in Leukemic Phase and Positive for CD13. Hematology Reports. 2017; 9(4):7437. https://doi.org/10.4081/hr.2017.7437

Chicago/Turabian Style

Carulli, Giovanni, Eugenio Mario Ciancia, Francesco Caracciolo, Paola Sammuri, Cristiana Domenichini, Maria Immacolata Ferreri, Alessia Di Vita, Virginia Ottaviano, Martina Rousseau, and Mario Petrini. 2017. "A Rare Case of De Novo CD5+ Diffuse Large B-Cell Lymphoma in Leukemic Phase and Positive for CD13" Hematology Reports 9, no. 4: 7437. https://doi.org/10.4081/hr.2017.7437

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