Improving Exposure Assessment Using Non-Targeted and Suspect Screening: The ISO/IEC 17025: 2017 Quality Standard as a Guideline
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Measurement Uncertainties
- “Measurement uncertainties” in “7.2 Selection and verification of methods”
- “Measurement uncertainties” in “7.6 Evaluation of measurement uncertainty”
3.2. Validity of the Method
3.3. Validation of Results
3.4. Report
3.5. Software
3.6. Non-Targeted Critical Challenges
3.6.1. Digital Archives
3.6.2. Sample Identification and Registration
3.6.3. File Conversion to Open Formats
3.6.4. LIMS Compatibility with Non-Targeted Data
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ISO/IEC 17025: 2017 |
---|
1 Scope |
2 Normative references |
3 Terms and definitions |
4 General requirements |
5 Structural requirements |
6 Resource requirements |
7 Process requirements 7.1—Review of requests, tenders and contracts 7.2—Selection, verification and validation of methods 7.3—Sampling 7.4—Handling of test or calibration items 7.5—Technical records 7.6—Evaluation of measurement uncertainty 7.7—Ensuring the validity of results 7.8—Reporting of results 7.9—Complaints 7.10—Nonconforming work 7.11—Control of data and information management |
8 Management system requirements |
Annex A Metrological traceability Annex B Management system options |
ISO Requirements | Discussion Topic | Non-Targeted and Suspect Screening Specificities | |||
---|---|---|---|---|---|
7. Process Requirements | |||||
7.2 | Selection, verification and validation of methods | 7.2.1 | Selection and verification of methods | “Measurement uncertainties” | Qualitative criteria: Annotation
|
Quantitative criteria
| |||||
7.2.2 | Validity of methods | “Validity of the method” | Identification of influence factors
| ||
Method Validation Strategy
| |||||
Use of traceable mass calibrant for HRMS platforms
| |||||
Participation in collaborative trials
| |||||
7.6 | Evaluation of measurement uncertainty | “Measurement uncertainties” | Identification of influence factors
| ||
7.7 | Ensuring the validity of results | “Validity of results” | Systematic monitoring of results
| ||
7.8 | Reporting of results | “Report” | Definition of relevant information and format
| ||
7.11 | Control of data and information management | “Software” | Pre-processing and annotation software validation
|
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Monteiro Bastos da Silva, J.; Chaker, J.; Martail, A.; Costa Moreira, J.; David, A.; Le Bot, B. Improving Exposure Assessment Using Non-Targeted and Suspect Screening: The ISO/IEC 17025: 2017 Quality Standard as a Guideline. J. Xenobiot. 2021, 11, 1-15. https://doi.org/10.3390/jox11010001
Monteiro Bastos da Silva J, Chaker J, Martail A, Costa Moreira J, David A, Le Bot B. Improving Exposure Assessment Using Non-Targeted and Suspect Screening: The ISO/IEC 17025: 2017 Quality Standard as a Guideline. Journal of Xenobiotics. 2021; 11(1):1-15. https://doi.org/10.3390/jox11010001
Chicago/Turabian StyleMonteiro Bastos da Silva, Juliana, Jade Chaker, Audrey Martail, Josino Costa Moreira, Arthur David, and Barbara Le Bot. 2021. "Improving Exposure Assessment Using Non-Targeted and Suspect Screening: The ISO/IEC 17025: 2017 Quality Standard as a Guideline" Journal of Xenobiotics 11, no. 1: 1-15. https://doi.org/10.3390/jox11010001