Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
Abstract
:1. Introduction
2. Subjects and Methods
2.1. Study Population
2.2. Screening for Celiac Disease
2.3. Study Design
2.4. Dietary Assessment
2.5. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Acknowledgments
Colorado Clinical Center
Finland Clinical Center
Georgia/Florida Clinical Center
Germany Clinical Center
Sweden Clinical Center
Washington Clinical Center
Pennsylvania Satellite Center
Data Coordinating Center
Project scientist
Autoantibody Reference Laboratories
HLA Reference Laboratory
Repository
Other contributors
Committees
Trial Identification Number
Conflicts of Interest
References
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Matching Variable | Cases N = 207 (%) |
---|---|
Sex | |
- Female | 131 (63.3) |
- Male | 76 (36.7) |
Birth year | |
- 2004 | 11 (5.3) |
- 2005 | 39 (18.8) |
- 2006 | 28 (13.5) |
- 2007 | 41 (19.8) |
- 2008 | 37 (17.9) |
- 2009 | 46 (22.2) |
- 2010 | 5 (2.4) |
HLA-genotype | |
- DQ2/DQ8 | 64 (30.9) |
- DQ8/DQ8 | 35 (16.9) |
- DQ2/DQ2 | 100 (48.3) |
- Other | 8 (3.9) |
Time point | Number of cases analyzed | Number of cases missing intake | Milk powder intake (g/day) | Milk powder intake (g/kg/day) | ||
---|---|---|---|---|---|---|
OR (CI 95%) | p-value | OR (CI 95%) | p-value | |||
Last intake 1 | 207 | 0 | 1.0 (0.99–1.01) | 0.937 | 0.99 (0.87–1.13) | 0.861 |
Total intake 2 | 207 | 0 | 1.0 (1.0–1.00) | 0.662 | 1.0 (0.98–1.03) | 0.763 |
Intake at | ||||||
3 months | 207 | 0 | 0.99 (0.97–1.01) | 0.159 | 0.92 (0.83–1.02) | 0.125 |
6 months | 202 | 5 | 1.0 (0.99–1.02) | 0.643 | 1.02 (0.91–1.13) | 0.788 |
9 months | 198 | 9 | 1.01 (1.0–1.02) | 0.069 | 1.09 (0.99–1.19) | 0.072 |
12 months | 192 | 9 | 1.01 (1.0–1.02) | 0.181 | 1.08 (0.96–1.21) | 0.184 |
18 months | 146 | 21 | 1.0 (0.98–1.02) | 0.983 | 1.01 (0.84–1.21) | 0.923 |
24 months | 103 | 19 | 0.99 (0.97–1.01) | 0.202 | 0.88 (0.69–1.12) | 0.301 |
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Hård af Segerstad, E.M.; Lee, H.-S.; Andrén Aronsson, C.; Yang, J.; Uusitalo, U.; Sjöholm, I.; Rayner, M.; Kurppa, K.; Virtanen, S.M.; Norris, J.M.; et al. Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study. Nutrients 2018, 10, 550. https://doi.org/10.3390/nu10050550
Hård af Segerstad EM, Lee H-S, Andrén Aronsson C, Yang J, Uusitalo U, Sjöholm I, Rayner M, Kurppa K, Virtanen SM, Norris JM, et al. Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study. Nutrients. 2018; 10(5):550. https://doi.org/10.3390/nu10050550
Chicago/Turabian StyleHård af Segerstad, Elin M., Hye-Seung Lee, Carin Andrén Aronsson, Jimin Yang, Ulla Uusitalo, Ingegerd Sjöholm, Marilyn Rayner, Kalle Kurppa, Suvi M. Virtanen, Jill M. Norris, and et al. 2018. "Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study" Nutrients 10, no. 5: 550. https://doi.org/10.3390/nu10050550