A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Methodology
2.2. Study Population
2.3. Laboratory Tests
2.4. Statistical Analyses
3. Results
3.1. Evolution of 25(OH)D3
3.2. Evolution of 1,25(OH)2D3
3.3. Time to Definite Achievement of 25(OH)D3 Target
3.4. Safety Assessment
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Monthly Regimen n = 30 | Daily Regimen n = 30 | ||
---|---|---|---|
Age (years) | |||
Mean ± SD | 29.8 ± 9.5 | 29.4 ± 7.7 | |
[min–max] | [19.0–53.0] | [19.0–44.0] | |
Gender | |||
Male | N (%) | 9 (30%) | 13 (43.33%) |
Female | N (%) | 21 (70%) | 17 (56.67%) |
BMI (kg/m2) | Mean ± SD | 22.0 ± 2.1 | 21.9 ± 1.9 |
[min–max] | [18.2–25.0] | [18.3–25.0] |
Daily Regimen (Mean ± SD) | Monthly Regimen (Mean ± SD) | |
---|---|---|
ALBUMIN (g/L) | ||
Baseline | 46.7 ± 2.5 | 46.9 ± 2.3 |
Day 105 | 46.6 ± 2.4 | 46.1 ± 2.4 |
Change (Day 105—Baseline) * | −0.1 ± 2.3 | −0.8 ± 2.3 |
CREATININE (mg/dL) | ||
Baseline | 0.8 ± 0.2 | 0.8 ± 0.1 |
Day 105 | 0.8 ± 0.2 | 0.9 ± 0.1 |
Change (Day 105—Baseline) * | −0.0 ± 0.1 | 0.0 ± 0.1 |
PHOSPHATES (mmol/L) | ||
Baseline | 1.0 ± 0.2 | 1.1 ± 0.2 |
Day 105 | 1.0 ± 0.2 | 1.1 ± 0.2 |
Change (Day 105—Baseline) * | 0.0 ± 0.1 | 0.0 ± 0.2 |
ALKALINE PHOSPHATASE (IU/L) | ||
Baseline | 57.0 ± 17.5 | 58.7 ± 16.2 |
Day 105 | 57.6 ± 17.7 | 58.4 ± 16.9 |
Change (Day 105—Baseline) * | 0.6 ± 7.6 | −0.3 ± 5.0 |
CORRECTED CALCIUM (mmol/L) | ||
Baseline | 2.2 ± 0.1 | 2.2 ± 0.1 |
Day 105 | 2.2 ± 0.1 | 2.2 ± 0.1 |
Change (Day 105—Baseline) * | −0.0 ± 0.1 | −0.0 ± 0.1 |
PTH (ng/L) | ||
Baseline | 18.2 ± 6.0 | 22.3 ± 10.7 |
Day 105 | 16.5 ± 6.1 | 20.0 ± 9.0 |
Change (Day 105—Baseline) * | −1.6 ± 4.8 | −2.3 ± 9.1 |
FGF23 (pg/mL) | ||
Baseline | 51.9 ± 16.4 | 57.3 ± 16.3 |
Day 105 | 63.0 ± 18.8 | 63.6 ± 14.3 |
Change (Day 105—Baseline) * | 11.1 ± 14.8 | 6.3 ± 15.9 |
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De Niet, S.; Coffiner, M.; Da Silva, S.; Jandrain, B.; Souberbielle, J.-C.; Cavalier, E. A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation. Nutrients 2018, 10, 659. https://doi.org/10.3390/nu10060659
De Niet S, Coffiner M, Da Silva S, Jandrain B, Souberbielle J-C, Cavalier E. A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation. Nutrients. 2018; 10(6):659. https://doi.org/10.3390/nu10060659
Chicago/Turabian StyleDe Niet, Sophie, Monte Coffiner, Stéphanie Da Silva, Bernard Jandrain, Jean-Claude Souberbielle, and Etienne Cavalier. 2018. "A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation" Nutrients 10, no. 6: 659. https://doi.org/10.3390/nu10060659
APA StyleDe Niet, S., Coffiner, M., Da Silva, S., Jandrain, B., Souberbielle, J. -C., & Cavalier, E. (2018). A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3 Supplementation. Nutrients, 10(6), 659. https://doi.org/10.3390/nu10060659