Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Clarified Açaí (Euterpe Oleracea, Mart.) Juice for Human Consumption
2.3. Analysis of the Juice Composition
2.4. Treatments and Samples Collection
2.5. Open Field Test
2.6. Rotarod Test
2.7. Pole Test
2.8. Quantitation of the Total Protein Content
2.9. Assay of Lipid Peroxidation
2.10. Quantitation of Nitrite Levels
2.11. Telomerase Reverse Transcriptase (TERT) mRNA Expression in the Brain
2.12. Assay of Mercury Content in the Brain
2.13. Statistical Analysis
3. Results
3.1. Composition of the Euterpe Oleracea Juice for Human Consumption
3.2. Behavioral Analysis
3.3. Analysis of Oxidative Stress
3.4. Telomerase Reverse Transcriptase (TERT) mRNA Expression in the Brain
3.5. Analysis of Mercury Content in the Brain
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Phenolic Compound | Content (mg/L) | Content (%) |
---|---|---|
Cyanidin 3-rutinoside | 448 | 63.9% * |
Cyanidin 3-glucoside | 184 | 26.2% * |
Taxifolin deoxyhexose | 308 | 18.5% ** |
Orientin | 381 | 22.9% ** |
Homoorientin | 247 | 14.8% ** |
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Crespo-López, M.E.; Soares, E.S.; Macchi, B.d.M.; Santos-Sacramento, L.; Takeda, P.Y.; Lopes-Araújo, A.; Paraense, R.S.d.O.; Souza-Monteiro, J.R.; Augusto-Oliveira, M.; Luz, D.A.; et al. Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption. Nutrients 2019, 11, 2585. https://doi.org/10.3390/nu11112585
Crespo-López ME, Soares ES, Macchi BdM, Santos-Sacramento L, Takeda PY, Lopes-Araújo A, Paraense RSdO, Souza-Monteiro JR, Augusto-Oliveira M, Luz DA, et al. Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption. Nutrients. 2019; 11(11):2585. https://doi.org/10.3390/nu11112585
Chicago/Turabian StyleCrespo-López, Maria Elena, Ericks Sousa Soares, Barbarella de Matos Macchi, Leticia Santos-Sacramento, Priscila Yuki Takeda, Amanda Lopes-Araújo, Ricardo Sousa de Oliveira Paraense, José Rogério Souza-Monteiro, Marcus Augusto-Oliveira, Diandra Araújo Luz, and et al. 2019. "Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption" Nutrients 11, no. 11: 2585. https://doi.org/10.3390/nu11112585