Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Exercise-Dependent Attenuation of Diet-Induced Glucose Intolerance
3.2. Exercise-Dependent Increase in Diet-Induced Hepatic Inflammatory Response
3.3. Exercise-Dependent Reduction of Diet-Induced Hepatic Cholesterol Overload and Oxidative Stress
3.4. Possible Contribution of Exercise-Dependent Hepatic FGF21 Production to the Reduction of Diet-Induced Systemic Glucose Intolerance
4. Discussion
4.1. Exercise-Dependent Augmentation of Hepatic Inflammation
4.2. Impact of Exercise on Severe Oxidative Stress in Liver
4.3. Impact of Exercise on Glucose Tolerance
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Henkel, J.; Buchheim-Dieckow, K.; Castro, J.P.; Laeger, T.; Wardelmann, K.; Kleinridders, A.; Jöhrens, K.; Püschel, G.P. Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH. Nutrients 2019, 11, 2709. https://doi.org/10.3390/nu11112709
Henkel J, Buchheim-Dieckow K, Castro JP, Laeger T, Wardelmann K, Kleinridders A, Jöhrens K, Püschel GP. Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH. Nutrients. 2019; 11(11):2709. https://doi.org/10.3390/nu11112709
Chicago/Turabian StyleHenkel, Janin, Katja Buchheim-Dieckow, José P. Castro, Thomas Laeger, Kristina Wardelmann, André Kleinridders, Korinna Jöhrens, and Gerhard P. Püschel. 2019. "Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH" Nutrients 11, no. 11: 2709. https://doi.org/10.3390/nu11112709
APA StyleHenkel, J., Buchheim-Dieckow, K., Castro, J. P., Laeger, T., Wardelmann, K., Kleinridders, A., Jöhrens, K., & Püschel, G. P. (2019). Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH. Nutrients, 11(11), 2709. https://doi.org/10.3390/nu11112709