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Volume 11
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10.3390/nu11112778
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Article

Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial

by
Carmelinda Ruggiero
1,*,
Marta Baroni
1,
Vittorio Bini
2,
Annalisa Brozzetti
2,
Luca Parretti
1,
Elisa Zengarini
3,
Maria Lapenna
1,
Pierluigi Antinolfi
4,
Alberto Falorni
2,
Patrizia Mecocci
1 and
Virginia Boccardi
1
1
Gerontology and Geriatrics Institute, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, 1 06123 P.le Menghini, Italy
2
Department of Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Santa Maria della Misericordia Hospital, 1 06123 P.le Menghini, Italy
3
Geriatric Medicine and Geriatric Emergency Care, Italian National Research Center on Aging (IRCCS INRCA), 60127 Ancona, Italy
4
Division of Orthopedics and Trauma Surgery, Santa Maria della Misericordia Hospital, 06123 Perugia, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2778; https://doi.org/10.3390/nu11112778
Submission received: 6 October 2019 / Revised: 12 November 2019 / Accepted: 12 November 2019 / Published: 15 November 2019
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Abstract

Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment. Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01). Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04). Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites. In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels.
Keywords: calcifediol; cholecalciferol; bone markers; oldest-old; polypharmacy; sarcopenia calcifediol; cholecalciferol; bone markers; oldest-old; polypharmacy; sarcopenia

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MDPI and ACS Style

Ruggiero, C.; Baroni, M.; Bini, V.; Brozzetti, A.; Parretti, L.; Zengarini, E.; Lapenna, M.; Antinolfi, P.; Falorni, A.; Mecocci, P.; et al. Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial. Nutrients 2019, 11, 2778. https://doi.org/10.3390/nu11112778

AMA Style

Ruggiero C, Baroni M, Bini V, Brozzetti A, Parretti L, Zengarini E, Lapenna M, Antinolfi P, Falorni A, Mecocci P, et al. Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial. Nutrients. 2019; 11(11):2778. https://doi.org/10.3390/nu11112778

Chicago/Turabian Style

Ruggiero, Carmelinda, Marta Baroni, Vittorio Bini, Annalisa Brozzetti, Luca Parretti, Elisa Zengarini, Maria Lapenna, Pierluigi Antinolfi, Alberto Falorni, Patrizia Mecocci, and et al. 2019. "Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial" Nutrients 11, no. 11: 2778. https://doi.org/10.3390/nu11112778

APA Style

Ruggiero, C., Baroni, M., Bini, V., Brozzetti, A., Parretti, L., Zengarini, E., Lapenna, M., Antinolfi, P., Falorni, A., Mecocci, P., & Boccardi, V. (2019). Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial. Nutrients, 11(11), 2778. https://doi.org/10.3390/nu11112778

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