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Nutrients
Volume 11
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10.3390/nu11122865
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Review

Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression

by
Jose M. Comeche
1,
Iris Comino
1,
Cesare Altavilla
1,
Jose Tuells
1,
Ana Gutierrez-Hervas
2,* and
Pablo Caballero
1
1
Department of Community Nursing, Preventive Medicine and Public Health and History of Science, University of Alicante, San Vicente del Raspeig, 03690 Alicante, Spain
2
Department of Nursing, University of Alicante, San Vicente del Raspeig, 03690 Alicante, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2865; https://doi.org/10.3390/nu11122865
Submission received: 17 October 2019 / Revised: 15 November 2019 / Accepted: 19 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Dietary Patterns, Dietary Indices for Colorectal Cancer, Mortality and the Related Disease)
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Abstract

Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and characterized by the inflammation of the gastrointestinal tract. This study is to understand how the use of parenteral nutrition (PN) can affect the adult population diagnosed with IBD. We conducted a systematic review, meta-analysis, and meta-regression. From the different databases (MEDLINE, Scopus, Cochrane, LILACS, CINAHL, WOS), we found 119 registers with an accuracy of 16% (19 registers). After a full-text review, only 15 research studies were selected for qualitative synthesis and 10 for meta-analysis and meta-regression. The variables used were Crohn’s Disease Activity Index (CDAI), albumin, body weight (BW), and postoperative complications (COM). PN has shown to have efficacy for the treatment of IBD and is compatible with other medicines. The CDAI and albumin improve, although the effect of PN is greater after a while. However, the effect on the albumin could be less than the observed value in the meta-analysis due to possible publication bias. The BW does not change after intervention. COM utilizing PN has been observed, although the proportion is low. More studies specifically referring to ulcerative colitis (UC) and Crohn’s disease (CD) are needed to develop more concrete clinical results.
Keywords: inflammatory bowel diseases; parenteral nutrition; systematic review; meta-analysis; Crohn disease inflammatory bowel diseases; parenteral nutrition; systematic review; meta-analysis; Crohn disease

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MDPI and ACS Style

Comeche, J.M.; Comino, I.; Altavilla, C.; Tuells, J.; Gutierrez-Hervas, A.; Caballero, P. Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression. Nutrients 2019, 11, 2865. https://doi.org/10.3390/nu11122865

AMA Style

Comeche JM, Comino I, Altavilla C, Tuells J, Gutierrez-Hervas A, Caballero P. Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression. Nutrients. 2019; 11(12):2865. https://doi.org/10.3390/nu11122865

Chicago/Turabian Style

Comeche, Jose M., Iris Comino, Cesare Altavilla, Jose Tuells, Ana Gutierrez-Hervas, and Pablo Caballero. 2019. "Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression" Nutrients 11, no. 12: 2865. https://doi.org/10.3390/nu11122865

APA Style

Comeche, J. M., Comino, I., Altavilla, C., Tuells, J., Gutierrez-Hervas, A., & Caballero, P. (2019). Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression. Nutrients, 11(12), 2865. https://doi.org/10.3390/nu11122865

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