Congenital Lactase Deficiency: Mutations, Functional and Biochemical Implications, and Future Perspectives
Round 1
Reviewer 1 Report
This review on lactase-phlorizin hydrolase (LPH) is a very focused, well organized, and clearly written review. The authors present a good background on the pbysiology of this enzyme and considerations for when its deficiency may cause disease. The review is clear and conservatively written. It is stated clearly what we know and what is suspected. Consideration of the structure activity relationship is well considered in the context of what is known of active regions of LPH. A good consideration of many congenital mutations is presented and how these might effect function. It was nice to see consideration for heterozygotes presented. I have therefore no recommendations.
Reviewer 2 Report
Nice review by a well respected authority in the area.
