Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Patient Enrolment
2.2. Statistical Analysis
3. Results
3.1. Descriptive Statistics
3.2. Qualitative Variables Study
3.3. Linear Correlation Study of Quantitative Variables
3.4. Vitamin D Progression
3.5. Categorical Variables Study
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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CI a (95%) | ||||||||
---|---|---|---|---|---|---|---|---|
Variable | Group | Mean | StDev | CI− | CI+ | Skewness | Kurtosis | MSSD |
Vitamin D | S | 40.43 | 12.7 | 37.0 | 43.9 | 1.34 | 1.42 | 78 |
MD | 24.36 | 4.7 | 23.3 | 25.5 | 0.32 | −0.16 | 17 | |
SD | 17.83 | 8.1 | 16.3 | 19.3 | 0.85 | 0.39 | 65 | |
CRP | S | 2.28 | 2.37 | 1.8 | 2.8 | 1.82 | 3.5 | 1.5 |
MD | 2.80 | 3.07 | 2.3 | 3.3 | 1.71 | 3.01 | 4.3 | |
SD | 23.6 | 51.0 | 16 | 31 | 4.48 | 24.2 | 1102 | |
FC | S | 54 | 64 | 39 | 69 | 4.09 | 19.72 | 2567 |
MD | 141 | 164 | 111 | 172 | 1.81 | 3.00 | 15,020 | |
SD | 868 | 1278 | 665 | 1070 | 2.31 | 5.24 | 508,909 | |
FBG | S | 423 | 93 | 401 | 445 | 0.35 | −0.51 | 4140 |
MD | 412 | 107 | 392 | 432 | 0.57 | −0.13 | 6703 | |
SD | 497 | 133 | 475 | 517 | 0.08 | −0.77 | 5576 |
CI a (95%) | ||||||||
---|---|---|---|---|---|---|---|---|
Variable | Group | Min | Q1 | Median | Q3 | Max | CI− | CI+ |
Vitamin D | S | 20.5 | 32.2 | 36.2 | 43.0 | 74.30 | 34.1 | 43.9 |
MD | 15.3 | 20.6 | 24.7 | 27.4 | 37.5 | 22.4 | 25.5 | |
SD | 4.5 | 12.2 | 15.1 | 22.7 | 45.7 | 14.3 | 19.3 | |
CRP | S | 0.20 | 0.60 | 1.45 | 2.97 | 11.8 | 0.9 | 2.0 |
MD | 0.20 | 0.60 | 1.50 | 3.82 | 16.5 | 1.1 | 2.2 | |
SD | 0.30 | 1.90 | 5.60 | 15.6 | 364 | 4.5 | 7 | |
FC | S | 19.6 | 26.7 | 29.7 | 50.7 | 434 | 28 | 37 |
MD | 17 | 27.6 | 63 | 229 | 738 | 43 | 98 | |
SD | 19 | 97 | 346 | 1065 | 6450 | 216 | 444 | |
FBG | S | 262 | 356 | 411 | 491 | 664 | 387 | 446 |
MD | 201 | 325 | 406 | 475 | 700 | 365 | 432 | |
SD | 151 | 390 | 478 | 602 | 813 | 456 | 502 |
Clinical Characteristic | Number of Participants (Percentage) or Mean ± Standard Deviation | |
---|---|---|
Age, years | 43.7 ± 15.9 | |
Female sex | 39 (46) | |
Crohn’s disease | 60 (71) | |
Ulcerative colitis | 25 (29) | |
Perianal disease | 4 (5) | |
Extraintestinal manifestations | 10 (12) | |
Vitamin D supplementation | 44 (52) | |
Current therapy | Anti-TNFα | 47 (55) |
Vedolizumab | 8 (9) | |
Ustekinumab | 1 (1) | |
Steroids | 21 (25) | |
Azathioprine | 31 (36) | |
Methotrexate | 2 (2) |
FC, µg/g | CRP, mg/dL | ||||
---|---|---|---|---|---|
Group | Median | Q3–Q1 | Median | Q3–Q1 | |
Not supplemented | S | 33 | 25 | 1.3 | 1.8 |
MD | 85 | 211 | 1.9 | 4.2 | |
SD | 524 | 2230 | 8.9 | 3.1 | |
Supplemented | S | 29 | 38 | 2.3 | 4.6 |
MD | 55 | 328 | 2.1 | 4.9 | |
SD | 362 | 943 | 6.7 | 3.1 |
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López-Muñoz, P.; Beltrán, B.; Sáez-González, E.; Alba, A.; Nos, P.; Iborra, M. Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients. Nutrients 2019, 11, 1059. https://doi.org/10.3390/nu11051059
López-Muñoz P, Beltrán B, Sáez-González E, Alba A, Nos P, Iborra M. Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients. Nutrients. 2019; 11(5):1059. https://doi.org/10.3390/nu11051059
Chicago/Turabian StyleLópez-Muñoz, Pedro, Belén Beltrán, Esteban Sáez-González, Amparo Alba, Pilar Nos, and Marisa Iborra. 2019. "Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients" Nutrients 11, no. 5: 1059. https://doi.org/10.3390/nu11051059