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Nutrients
Volume 11
Issue 8
10.3390/nu11081836
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Article

Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study

by
Helen Robinson
1,*,
Helen Barrett
2,
Luisa Gomez-Arango
3,
H. David McIntyre
2,
Leonie Callaway
4 and
Marloes Dekker Nitert
3
1
Department of Obstetric Medicine, Royal Brisbane and Women’s Hospital, Butterfield St, Herston, QLD 4029, Australia
2
Mater Research Institute, The University of Queensland, Brisbane, QLD 4101, Australia
3
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia
4
Women’s and Newborn Services, Royal Brisbane and Women’s Hospital, Butterfield St, Herston, QLD 4029, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1836; https://doi.org/10.3390/nu11081836
Submission received: 18 July 2019 / Revised: 3 August 2019 / Accepted: 6 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue Nutrition for Gestational Diabetes)
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Abstract

The gut microbiome in pregnancy has been associated with various maternal metabolic and hormonal markers involved in glucose metabolism. Maternal ketones are of particular interest due to the rise in popularity of low-carbohydrate diets. We assessed for differences in the composition of the gut microbiota in pregnant women with and without ketonuria at 16 weeks gestation. Fecal samples were obtained from 11 women with fasting ketonuria and 11 matched controls. The samples were analyzed to assess for differences in gut microbiota composition by 16S rRNA sequencing. Supervised hierarchical clustering analysis showed significantly different beta-diversity between women with and without ketonuria, but no difference in the alpha-diversity. Group comparisons and network analysis showed that ketonuria was associated with an increased abundance of the butyrate-producing genus Roseburia. The bacteria that contributed the most to the differences in the composition of the gut microbiota included Roseburia, Methanobrevibacter, Uncl. RF39, and Dialister in women with ketonuria and Eggerthella, Phascolarctobacterium, Butyricimonas, and Uncl. Coriobacteriaceae in women without ketonuria. This study found that the genus Roseburia is more abundant in the gut microbiota of pregnant women with ketonuria. Roseburia is a butyrate producing bacterium and may increase serum ketone levels.
Keywords: microbiome; pregnancy; obesity; ketonuria; Roseburia microbiome; pregnancy; obesity; ketonuria; Roseburia

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MDPI and ACS Style

Robinson, H.; Barrett, H.; Gomez-Arango, L.; McIntyre, H.D.; Callaway, L.; Dekker Nitert, M. Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study. Nutrients 2019, 11, 1836. https://doi.org/10.3390/nu11081836

AMA Style

Robinson H, Barrett H, Gomez-Arango L, McIntyre HD, Callaway L, Dekker Nitert M. Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study. Nutrients. 2019; 11(8):1836. https://doi.org/10.3390/nu11081836

Chicago/Turabian Style

Robinson, Helen, Helen Barrett, Luisa Gomez-Arango, H. David McIntyre, Leonie Callaway, and Marloes Dekker Nitert. 2019. "Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study" Nutrients 11, no. 8: 1836. https://doi.org/10.3390/nu11081836

APA Style

Robinson, H., Barrett, H., Gomez-Arango, L., McIntyre, H. D., Callaway, L., & Dekker Nitert, M. (2019). Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study. Nutrients, 11(8), 1836. https://doi.org/10.3390/nu11081836

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