Asthma and Dietary Intake of Fish, Seaweeds, and Fatty Acids in Korean Adults
Abstract
:1. Introduction
2. Methods
2.1. Study Population
2.2. Definition of Asthma
2.3. Dietary Assessment
2.4. Covariates
2.5. Statistical Analysis
3. Results
3.1. Characteristics Based on the Presence of Asthma
3.2. Daily Food and Nutrient Intake Based on the Presence of Asthma
3.3. Association between Dietary Intake and Asthma
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Variables | Doctor-Diagnosed Asthma | Medication-Prescribed Asthma | ||||
---|---|---|---|---|---|---|
Without (n = 12,723) | With (n = 315) | p-Value | Without (n = 12,905) | With (n = 133) | p-Value | |
Sex | ||||||
Male | 5113 (50.6) | 105 (45.1) | 0.1049 | 5175 (50.5) | 43 (45.0) | 0.2904 |
Female | 7610 (49.4) | 210 (54.9) | 7730 (49.5) | 90 (55.0) | ||
Age (years) | 41.2 ± 0.2 | 39.2 ± 1.0 | 0.0335 | 41.1 ± 0.2 | 44.9 ± 1.4 | 0.0063 |
BMI (kg/m2) | 23.8 ± 0.0 | 24.1 ± 0.2 | 0.1387 | 23.8 ± 0.0 | 24.8 ± 0.4 | 0.0106 |
Residential area | ||||||
Urban | 10611 (85.7) | 256 (84.2) | 0.4917 | 10765 (85.7) | 102 (81.4) | 0.2037 |
Rural | 2112 (14.3) | 59 (15.8) | 2140 (14.3) | 31 (18.6) | ||
Education level | ||||||
<High school graduate | 6170 (43.5) | 161 (42.3) | 0.8637 | 6241 (43.3) | 90 (58.0) | 0.0185 |
High school graduate | 2090 (17.7) | 51 (19.0) | 2129 (17.8) | 12 (11.8) | ||
≥College graduate | 4429 (38.8) | 102 (38.7) | 4500 (38.9) | 31 (30.1) | ||
Household income | ||||||
Low | 1192 (9.0) | 42 (11.2) | 0.1535 | 1210 (9.0) | 24 (15.7) | 0.0993 |
Moderately low | 3142 (24.3) | 65 (21.3) | 3176 (24.2) | 31 (22.6) | ||
Moderately high | 3963 (31.5) | 111 (36.4) | 4033 (31.6) | 41 (32.2) | ||
High | 4389 (35.3) | 97 (31.0) | 4449 (35.2) | 37 (29.5) | ||
Alcohol consumption | ||||||
Never | 1786 (13.2) | 59 (16.4) | 0.4215 | 1814 (13.2) | 31 (21.5) | 0.1548 |
≤1 drink/month | 3902 (32.1) | 97 (33.2) | 3960 (32.2) | 39 (31.0) | ||
2–4 drink/month | 3192 (29.3) | 69 (28.7) | 3241 (29.3) | 20 (21.1) | ||
2–3 drink/week | 2032 (18.7) | 47 (17.5) | 2060 (18.6) | 19 (19.3) | ||
≥4 drink/week | 747 (6.7) | 12 (4.2) | 752 (6.6) | 7 (7.1) | ||
Dietary supplement use | ||||||
Yes | 5861 (44.4) | 133 (41.1) | 0.2846 | 5938 (44.3) | 56 (40.8) | 0.4951 |
Smoking status | ||||||
Current smokers | 2172 (25.8) | 54 (25.0) | 0.6101 | 2202 (25.8) | 24 (29.4) | 0.8019 |
Ex-smokers | 379 (4.4) | 5 (2.9) | 382 (4.4) | 2 (3.5) | ||
Nonsmokers | 7974 (69.8) | 207 (72.0) | 81 (67.1) |
Variables | Doctor-Diagnosed Asthma | Medication-Prescribed Asthma | ||||
---|---|---|---|---|---|---|
Without (n = 12,723) | With (n = 315) | p-Value | Without (n = 12,905) | With (n = 133) | p-Value | |
Food intake (g) | ||||||
Cereals/potatoes/sugar products | 349.3 ± 2.3 | 333.2 ± 11.3 | 0.2961 | 349.1 ± 2.2 | 321.7 ± 16.1 | 0.0006 |
Beans/nuts/seeds | 44.0 ± 0.9 | 38.3 ± 4.1 | 0.5653 | 43.9 ± 0.9 | 41.5 ± 7.2 | 0.6520 |
Meats and eggs | 146.8 ± 1.9 | 132.7 ± 10.5 | 0.9874 | 146.6 ± 1.9 | 127.6 ± 17.5 | 0.8904 |
Fishes and shellfishes | 98.2 ± 1.9 | 83.1 ± 10.2 | 0.5890 | 97.9 ± 1.9 | 90.0 ± 20.8 | 0.8761 |
Fishes | 27.6 ± 0.7 | 22.4 ± 3.3 | 0.0923 | 27.5 ± 0.7 | 27.1 ± 5.8 | 0.5785 |
Milk and dairy products | 88.9 ± 1.8 | 110.2 ± 14.8 | 0.2664 | 89.1 ± 1.8 | 118.4 ± 29.9 | 0.3723 |
Fruit and vegetable | 518.1 ± 4.6 | 494.5 ± 24.9 | 0.8628 | 517.3 ± 4.6 | 534.1 ± 39.9 | 0.9614 |
Mushrooms | 6.7 ± 0.3 | 4.5 ± 0.8 | 0.0964 | 6.7 ± 0.3 | 4.9 ± 1.4 | 0.3942 |
Seaweeds | 24.7 ± 1.1 | 17.4 ± 3.3 | 0.0638 | 24.6 ± 1.1 | 13.5 ± 4.1 | 0.0110 |
Energy and nutrient intake | ||||||
Energy (kcal) | 2128.8 ± 9.8 | 2028.3 ± 58.3 | 0.0705 | 2127.0 ± 9.7 | 2056.5 ± 97.6 | 0.6463 |
Carbohydrate (g) | 312.0 ± 1.4 | 302.7 ± 8.3 | 0.7192 | 311.8 ± 1.4 | 302.2 ± 12.7 | 0.0195 |
Protein (g) | 75.2 ± 0.4 | 71.6 ± 3.0 | 0.4817 | 75.2 ± 0.4 | 74.3 ± 5.4 | 0.3215 |
Fat (g) | 50.6 ± 0.4 | 47.6 ± 2.0 | 0.7848 | 50.5 ± 0.4 | 47.2 ± 3.3 | 0.3143 |
Calcium (mg) | 501.8 ± 3.3 | 496.7 ± 25.5 | 0.4282 | 501.5 ± 3.3 | 524.7 ± 46.1 | 0.5543 |
Iron (mg) | 17.7 ± 0.2 | 16.0 ± 0.6 | 0.1972 | 17.6 ± 0.2 | 16.1 ± 1.0 | 0.0246 |
Thiamin (mg) | 2.1 ± 0.0 | 2.0 ± 0.1 | 0.9728 | 2.1 ± 0.0 | 2.1 ± 0.1 | 0.5263 |
Riboflavin (mg) | 1.5 ± 0.0 | 1.5 ± 0.1 | 0.1498 | 1.5 ± 0.0 | 1.6 ± 0.2 | 0.1721 |
Niacin (mg) | 17.4 ± 0.1 | 16.5 ± 0.7 | 0.8362 | 17.4 ± 0.1 | 17.2 ± 1.4 | 0.6666 |
Vitamin C (mg) | 100.5 ± 1.5 | 95.6 ± 7.5 | 0.8166 | 100.3 ± 1.5 | 110.3 ± 13.6 | 0.8952 |
Vitamin A (μgRE) | 751.9 ± 11.1 | 780.7 ± 75.2 | 0.6336 | 752.1 ± 11.1 | 798.2 ± 160.8 | 0.6804 |
Fatty acids | ||||||
SFA (g) | 14.7 ± 0.1 | 14.3 ± 0.7 | 0.3194 | 14.7 ± 0.1 | 14.5 ± 1.3 | 0.1252 |
MUFA (g) | 16.2 ± 0.1 | 15.3 ± 0.8 | 0.7624 | 16.2 ± 0.1 | 15.4 ± 1.2 | 0.1925 |
PUFA (g) | 12.2 ± 0.1 | 11.4 ± 0.6 | 0.9407 | 12.2 ± 0.1 | 11.0 ± 0.8 | 0.9465 |
n-3 (g) | 1.7 ± 0.0 | 1.5 ± 0.1 | 0.8966 | 1.7 ± 0.0 | 1.5 ± 0.1 | 0.6403 |
n-6 (g) | 10.6 ± 0.1 | 9.8 ± 0.5 | 0.9783 | 10.6 ± 0.1 | 9.6 ± 0.7 | 0.8517 |
n3/n6 | 0.18 ± 0.00 | 0.17 ± 0.01 | 0.0708 | 0.18 ± 0.00 | 0.16 ± 0.01 | 0.0275 |
EPA (mg) | 108.2 ± 2.6 | 96.2 ± 15.7 | 0.9384 | 107.6 ± 2.6 | 135.9 ± 37.0 | 0.3860 |
DHA (mg) | 187.7 ± 5.2 | 152.1 ± 22.5 | 0.5155 | 186.6 ± 5.1 | 205.4 ± 50.5 | 0.5818 |
Cholesterol (mg) | 283.5 ± 2.9 | 287.6 ± 19.0 | 0.4395 | 283.5 ± 2.8 | 291.7 ± 31.0 | 0.3442 |
Variable | Range (g) | Median (g) | Doctor-Diagnosed Asthma | Medication-Prescribed Asthma | ||||
---|---|---|---|---|---|---|---|---|
Prevalence (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | Prevalence (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | |||
Fish and shellfish | ||||||||
Q1 | <4.07 | 0 | 94/3259 (2.88) | 1 | 1 | 41/3259 (1.26) | 1 | 1 |
Q2 | 4.07–35.20 | 14.82 | 78/3260 (2.39) | 0.82 (0.60–1.13) | 0.90 (0.62–1.32) | 32/3260 (0.98) | 0.71 (0.42–1.20) | 0.77 (0.41–1.44) |
Q3 | 35.21–125.14 | 67.05 | 71/3260 (2.18) | 0.82 (0.58–1.17) | 0.75 (0.49–1.15) | 35/3260 (1.07) | 0.93 (0.56–1.55) | 0.71 (0.38–1.34) |
Q4 | >125.14 | 233.34 | 72/3259 (2.21) | 0.77 (0.54–1.10) | 0.85 (0.57–1.27) | 25/3259 (0.77) | 0.55 (0.31–0.98) | 0.57 (0.29–1.12) |
P for trend | 0.2705 | 0.6894 | 0.0501 | 0.1005 | ||||
Fish | ||||||||
Q1 | 0 | 0 | 135/4782 (2.82) | 1 | 1 | 51/4782 (1.07) | 1 | 1 |
Q2 | <2.49 | 1.09 | 43/1737 (2.48) | 0.73 (0.49–1.11) | 0.78 (0.49–1.24) | 17/1737 (0.98) | 0.78 (0.42–1.43) | 0.80 (0.38–1.69) |
Q3 | 2.49–24.01 | 7.46 | 74/3260 (2.27) | 0.65 (0.47–0.91) | 0.71 (0.48–1.04) | 36/3260 (1.10) | 0.71 (0.45–1.12) | 0.60 (0.34–1.07) |
Q4 | >24.01 | 69.32 | 63/3259 (1.93) | 0.71 (0.51–0.99) | 0.63 (0.41–0.97) | 29/3259 (0.89) | 0.91 (0.54–1.53) | 0.77 (0.40–1.50) |
P for trend | 0.1617 | 0.0637 | 0.9453 | 0.6532 | ||||
Seaweeds | ||||||||
Q1 | 0 | 0 | 141/5627 (2.51) | 1 | 1 | 62/5627 (1.10) | 1 | 1 |
Q2 | <1.00 | 0.50 | 27/896 (3.01) | 0.82 (0.50–1.34) | 0.78 (0.43–1.40) | 10/896 (1.12) | 0.84 (0.38–1.84) | 0.82 (0.30–2.24) |
Q3 | 1.01–7.47 | 3.07 | 75/3256 (2.30) | 0.87 (0.64–1.19) | 0.95 (0.66–1.36) | 34/3256 (1.04) | 0.88 (0.56–1.41) | 0.99 (0.57–1.75) |
Q4 | >7.47 | 28.84 | 72/3259 (2.21) | 0.72 (0.53–0.98) | 0.66 (0.44–1.00) | 27/3259 (0.83) | 0.52 (0.32–0.85) | 0.37 (0.19–0.70) |
P for trend | 0.0346 | 0.0300 | 0.0018 | <0.0001 |
Variable | Range (g) | Median (g) | Doctor-Diagnosed Asthma | Medication-Prescribed Asthma | ||||
---|---|---|---|---|---|---|---|---|
Prevalence (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | Prevalence (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | |||
Total fat | ||||||||
Q1 | <24.52 | 16.94 | 89/3259 (2.73) | 1 | 1 | 42/3259 (1.29) | 1 | 1 |
Q2 | 24.52–39.69 | 32.00 | 73/3260 (2.24) | 0.79 (0.55–1.14) | 0.75 (0.48–1.17) | 32/3260 (0.98) | 0.78 (0.46–1.32) | 0.76 (0.38–1.50) |
Q3 | 39.70–60.98 | 48.90 | 83/3260 (2.55) | 0.90 (0.64–1.26) | 0.92 (0.59–1.43) | 31/3260 (0.95) | 0.74 (0.47–1.17) | 0.96 (0.48–1.93) |
Q4 | >60.98 | 83.53 | 70/3259 (2.15) | 0.80 (0.55–1.16) | 1.04 (0.60–1.81) | 28/3259 (0.86) | 0.75 (0.44–1.27) | 1.61 (0.65–3.99) |
P for trend | 0.3792 | 0.6269 | 0.3702 | 0.2090 | ||||
SFA | ||||||||
Q1 | <6.36 | 4.21 | 783259 (2.39) | 1 | 1 | 41/3259 (1.26) | 1 | 1 |
Q2 | 6.36–11.02 | 8.67 | 82/3260 (2.52) | 1.18 (0.82–1.69) | 1.21 (0.78–1.89) | 26/3260 (0.80) | 0.67 (0.38-1.20) | 0.59 (0.83-1.15) |
Q3 | 11.03-17.73 | 13.96 | 77/3260 (2.36) | 1.15 (0.80-1.65) | 1.33 (0.84-2.11) | 38/3260 (1.17) | 1.05 (0.66-1.68) | 1.59 (0.83-3.08) |
Q4 | >17.73 | 25.05 | 78/3259 (2.39) | 1.11 (0.77-1.60) | 1.63 (0.97-2.73) | 28/3259 (0.86) | 0.80 (0.46-1.37) | 1.58 (0.74-3.38) |
P for trend | 0.7875 | 0.0743 | 0.7171 | 0.0871 | ||||
MUFA | ||||||||
Q1 | <6.90 | 4.55 | 87/3259 (2.67) | 1 | 1 | 42/3259 (1.29) | 1 | 1 |
Q2 | 6.90-12.04 | 9.48 | 79/3260 (2.42) | 0.98 (0.68-1.39) | 0.99 (0.63-1.55) | 31/3260 (0.95) | 0.89 (0.52-1.50) | 1.14 (0.57-2.27) |
Q3 | 12.05–19.76 | 15.24 | 78/3260 (2.39) | 0.91 (0.63–1.32) | 0.87 (0.54–1.40) | 31/3260 (0.95) | 0.75 (0.46–1.23) | 0.92 (0.41–2.08) |
Q4 | >19.76 | 27.87 | 71/3259 (2.18) | 0.87 (0.60–1.26) | 1.05 (0.57–1.93) | 29/3259 (0.89) | 0.84 (0.50–1.43) | 1.77 (0.66–4.76) |
P for trend | 0.4361 | 0.8685 | 0.5791 | 0.2505 | ||||
PUFA | ||||||||
Q1 | <5.57 | 3.76 | 95/3259 (2.92) | 1 | 1 | 48/3259 (1.47) | 1 | 1 |
Q2 | 5.57–9.24 | 7.36 | 64/3260 (1.96) | 0.67 (0.46–0.97) | 0.72 (0.45–1.16) | 27/3260 (0.83) | 0.56 (0.33–0.94) | 0.58 (0.28–1.18) |
Q3 | 9.25–14.92 | 11.71 | 87/3260 (2.67) | 1.04 (0.74–1.46) | 1.09 (0.70–1.69) | 30/3260 (0.92) | 0.85 (0.52–1.40) | 0.86 (0.42–1.75) |
Q4 | >14.92 | 21.0 | 69/3259 (2.12) | 0.74 (0.51–1.07) | 1.10 (0.66–1.84) | 28/3259 (0.86) | 0.55 (0.33–0.93) | 0.85 (0.37–1.99) |
P for trend | 0.3328 | 0.3753 | 0.0803 | 0.9308 | ||||
n–3 PUFA | ||||||||
Q1 | <0.65 | 0.41 | 91/3259 (2.79) | 1 | 1 | 49/3259 (1.50) | 1 | 1 |
Q2 | 0.65–1.19 | 0.90 | 77/3260 (2.36) | 0.82 (0.58–1.16) | 0.86 (0.57–1.29) | 28/3260 (0.86) | 0.55 (0.32–0.93) | 0.62 (0.31–1.22) |
Q3 | 1.20–2.10 | 1.56 | 81/3260 (2.48) | 0.80 (0.56–1.14) | 0.82 (0.53–1.26) | 27/3260 (0.83) | 0.47 (0.27–0.82) | 0.43 (0.21–0.89) |
Q4 | >2.10 | 3.07 | 66/3259 (2.03) | 0.74 (0.51–1.10) | 0.90 (0.57–1.40) | 29/3259 (0.89) | 0.63 (0.37–1.07) | 0.71 (0.33–1.51) |
P for trend | 0.1918 | 0.7609 | 0.2290 | 0.4776 | ||||
n–6 PUFA | ||||||||
Q1 | <4.65 | 3.09 | 93/3259 (2.85) | 1 | 1 | 48/3259 (1.47) | 1 | 1 |
Q2 | 4.65–7.85 | 6.24 | 72/3260 (2.21) | 0.82 (0.56–1.19) | 0.92 (0.58–1.45) | 28/3260 (0.86) | 0.64 (0.38–1.09) | 0.69 (0.35–1.36) |
Q3 | 7.86–12.93 | 10.04 | 81/3260 (2.48) | 0.99 (0.70–1.41) | 1.03 (0.65–1.63) | 29/3260 (0.89) | 0.79 (0.47–1.31) | 0.82 (0.38–1.74) |
Q4 | >12.93 | 18.30 | 69/3259 (2.12) | 0.75 (0.52–1.09) | 1.07 (0.63–1.82) | 28/3259 (0.86) | 0.54 (0.32–0.89) | 0.80 (0.32–1.98) |
P for trend | 0.2015 | 0.6872 | 0.0305 | 0.7295 | ||||
n–3/n–6 | ||||||||
Q1 | <0.10 | 0.08 | 92/3259 (2.82) | 1 | 1 | 45/3259 (1.38) | 1 | 1 |
Q2 | 0.10–0.13 | 0.12 | 68/3259 (2.09) | 0.78 (0.54–1.15) | 0.92 (0.59–1.43) | 29/3259 (0.89) | 0.60 (0.35–1.02) | 0.61 (0.32–1.16) |
Q3 | 0.14–0.19 | 0.16 | 75/3260 (2.30) | 0.89 (0.63–1.27) | 1.01 (0.66–1.58) | 33/3260 (1.01) | 0.75 (0.45–1.25) | 0.69 (0.36–1.31) |
Q4 | >0.19 | 0.30 | 80/3259 (2.45) | 0.92 (0.65–1.30) | 0.91 (0.58–1.43) | 26/3259 (0.80) | 0.59 (0.33–1.06) | 0.47 (0.22–0.99) |
P for trend | 0.9761 | 0.7471 | 0.1475 | 0.0563 | ||||
Cholesterol | ||||||||
Q1 | <93.07 | 48.68 | 97/3259 (2.98) | 1 | 1 | 45/3259 (1.38) | 1 | 1 |
Q2 | 93.07–202.34 | 142.84 | 62/3260 (1.90) | 0.61 (0.42–0.90) | 0.64 (0.41–0.99) | 33/3260 (1.01) | 0.76 (0.48–1.19) | 0.84 (0.48–1.49) |
Q3 | 202.35–361.02 | 272.54 | 81/3260 (2.48) | 0.86 (0.61–1.21) | 1.05 (0.73–1.51) | 27/3260 (0.83) | 0.60 (0.35–1.04) | 0.72 (0.37–1.42) |
Q4 | >361.02 | 534.53 | 75/3259 (2.30) | 0.87 (0.61–1.24) | 0.85 (0.56–1.31) | 28/3259 (0.86) | 0.88 (0.53–1.46) | 0.96 (0.50–1.85) |
P for trend | 0.9132 | 0.9354 | 0.8583 | 0.9555 |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Kim, E.-k.; Ju, S.-Y. Asthma and Dietary Intake of Fish, Seaweeds, and Fatty Acids in Korean Adults. Nutrients 2019, 11, 2187. https://doi.org/10.3390/nu11092187
Kim E-k, Ju S-Y. Asthma and Dietary Intake of Fish, Seaweeds, and Fatty Acids in Korean Adults. Nutrients. 2019; 11(9):2187. https://doi.org/10.3390/nu11092187
Chicago/Turabian StyleKim, Eun-kyung, and Se-Young Ju. 2019. "Asthma and Dietary Intake of Fish, Seaweeds, and Fatty Acids in Korean Adults" Nutrients 11, no. 9: 2187. https://doi.org/10.3390/nu11092187