Dietary Sodium Intake and Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources and Literature Searches
2.2. Study Selection
2.3. Data Extraction and Quality Assessment
2.4. Data Synthesis and Analysis
3. Results
3.1. Study Characteristics and Quality Assessment
3.2. Highest Versus Lowest Meta-Analysis
3.3. Dose-Response Meta-Analysis
3.4. Subgroup Analysis, Meta-Regression, and Sensitivity Analyses
3.5. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Subgroup Analysis | Number of Estimates | Summary RR (95% CI) | I2 (%) * | p Value * |
---|---|---|---|---|
Overall | 33 | 1.04 (1.01, 1.07) | 77 | 0.01 * |
Subregion | 0.06 | |||
Asia | 9 | 1.15 (1.01, 1.29) | 72 | |
Non-Asia | 23 | 1.03 (0.99, 1.07) | 75 | |
Multi-nation | 1 | 1.00 (0.97, 1.02) | - | |
Follow-up years | 0.88 | |||
Above ten years | 20 | 1.05 (1.00, 1.10) | 67 | |
Less than 10 years | 13 | 1.01 (1.01, 1.02) | 85 | |
Sodium assessment | 0.82 | |||
From diet | 19 | 1.05 (0.99, 1.11) | 76 | |
From Urine | 14 | 1.04 (1.00, 1.08) | 63 | |
Outcomes | 0.91 | |||
Total CVD | 14 | 1.05 (1.01, 1.09) | 81 | |
CVD mortality | 11 | 1.06 (0.94, 1.20) | 81 | |
Stroke | 5 | 1.04 (0.91, 1.19) | 73 | |
Coronary heart disease | 1 | 1.05 (0.97, 1.15) | - | |
Heart failure | 2 | 0.99 (0.89, 1.10) | 62 |
Meta Regression | Number of Estimates | Point Estimates | I2 (%) * | p Value * |
---|---|---|---|---|
Mean age (year) | 32 | 1.00 (0.99, 1.01) | 90 | 0.92 |
Percentage of women (%) | 33 | 1.00 (1.00, 1.00) | 90 | 0.89 |
Follow-up years (year) | 33 | 1.00 (0.99, 1.01) | 90 | 0.89 |
Study quality score | 33 | 1.01 (0.96, 1.06) | 86 | 0.60 |
Body mass index (kg/m2) | 22 | 0.99 (0.97, 1.02) | 91 | 0.62 |
Percentage of white participants (%) | 10 | 1.00 (1.00, 1.01) | 83 | 0.75 |
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Wang, Y.-J.; Yeh, T.-L.; Shih, M.-C.; Tu, Y.-K.; Chien, K.-L. Dietary Sodium Intake and Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-Analysis. Nutrients 2020, 12, 2934. https://doi.org/10.3390/nu12102934
Wang Y-J, Yeh T-L, Shih M-C, Tu Y-K, Chien K-L. Dietary Sodium Intake and Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-Analysis. Nutrients. 2020; 12(10):2934. https://doi.org/10.3390/nu12102934
Chicago/Turabian StyleWang, Yi-Jie, Tzu-Lin Yeh, Ming-Chieh Shih, Yu-Kang Tu, and Kuo-Liong Chien. 2020. "Dietary Sodium Intake and Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-Analysis" Nutrients 12, no. 10: 2934. https://doi.org/10.3390/nu12102934