Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

Rybak, Anna; Sethuraman, Aruna; Nikaki, Kornilia; Koeglmeier, Jutta; Lindley, Keith; Borrelli, Osvaldo

doi:10.3390/nu12113536

Open AccessReview

Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

by

Anna Rybak

^1,*

,

Aruna Sethuraman

¹,

Kornilia Nikaki

²

,

Jutta Koeglmeier

¹,

Keith Lindley

¹ and

Osvaldo Borrelli

¹

Department of Gastroenterology, the Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK

²

Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL, 26 Ashfield Street, Whitechapel, London E1 2AJ, UK

^*

Author to whom correspondence should be addressed.

Nutrients 2020, 12(11), 3536; https://doi.org/10.3390/nu12113536

Submission received: 19 October 2020 / Revised: 9 November 2020 / Accepted: 12 November 2020 / Published: 18 November 2020

(This article belongs to the Special Issue Nutrition in the Management of Short Bowel Syndrome and Intestinal Failure)

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Abstract

Gastrointestinal dysmotility is a common problem in a subgroup of children with intestinal failure (IF), including short bowel syndrome (SBS) and pediatric intestinal pseudo-obstruction (PIPO). It contributes significantly to the increased morbidity and decreased quality of life in this patient population. Impaired gastrointestinal (GI) motility in IF arises from either loss of GI function due to the primary disorder (e.g., neuropathic or myopathic disorder in the PIPO syndrome) and/or a critical reduction in gut mass. Abnormalities of the anatomy, enteric hormone secretion and neural supply in IF can result in rapid transit, ineffective antegrade peristalsis, delayed gastric emptying or gastroesophageal reflux. Understanding the underlying pathophysiologic mechanism(s) of the enteric dysmotility in IF helps us to plan an appropriate diagnostic workup and apply individually tailored nutritional and pharmacological management, which might ultimately lead to an overall improvement in the quality of life and increase in enteral tolerance. In this review, we have focused on the pathogenesis of GI dysmotility in children with IF, as well as the management and treatment options.

Keywords: GERD; intestinal failure; short bowel syndrome; dysmotility; pediatric intestinal pseudo-obstruction syndrome; gastroparesis; nutrition; children

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MDPI and ACS Style

Rybak, A.; Sethuraman, A.; Nikaki, K.; Koeglmeier, J.; Lindley, K.; Borrelli, O. Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure. Nutrients 2020, 12, 3536. https://doi.org/10.3390/nu12113536

AMA Style

Rybak A, Sethuraman A, Nikaki K, Koeglmeier J, Lindley K, Borrelli O. Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure. Nutrients. 2020; 12(11):3536. https://doi.org/10.3390/nu12113536

Chicago/Turabian Style

Rybak, Anna, Aruna Sethuraman, Kornilia Nikaki, Jutta Koeglmeier, Keith Lindley, and Osvaldo Borrelli. 2020. "Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure" Nutrients 12, no. 11: 3536. https://doi.org/10.3390/nu12113536

APA Style

Rybak, A., Sethuraman, A., Nikaki, K., Koeglmeier, J., Lindley, K., & Borrelli, O. (2020). Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure. Nutrients, 12(11), 3536. https://doi.org/10.3390/nu12113536

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Gastroesophageal Reflux Disease and Foregut Dysmotility in Children with Intestinal Failure

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