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Nutrients
Volume 12
Issue 2
10.3390/nu12020355
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Article

Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex

by
Giulia Sbrini
,
Paola Brivio
,
Marco Fumagalli
,
Flavio Giavarini
,
Donatella Caruso
,
Giorgio Racagni
,
Mario Dell’Agli
,
Enrico Sangiovanni
* and
Francesca Calabrese
Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 355; https://doi.org/10.3390/nu12020355
Submission received: 31 December 2019 / Revised: 23 January 2020 / Accepted: 27 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue Nutrition, Cognition and Brain Integrity)
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Abstract

A wide range of people in the world use natural remedies as primary approaches against illnesses. Accordingly, understanding the mechanisms of action of phytochemicals has become of great interest. In this context, Centella asiatica L. is extensively used, not only as anti-inflammatory or antioxidant agent but also as brain tonic. On this basis, the purpose of this study was to evaluate whether the chronic administration of C. asiatica L. to adult male rats was able to improve the expression of Bdnf, one of the main mediators of brain plasticity. Moreover, we assessed whether the treatment could affect the cognitive performance in the novel object recognition (NOR) test. We confirmed the presence of the main compounds in the plasma. Furthermore, C. asiatica L. administration induced an increase of Bdnf in the prefrontal cortex, and the administration of the higher dose of the extract was able to improve cognitive performance. Finally, the increase in the preference index in the NOR test was paralleled by a further increase in Bdnf expression. Overall, we highlight the ability of C. asiatica L. to affect brain functions by increasing Bdnf expression and by enhancing the cognitive performance.
Keywords: C. asiatica L.; Bdnf; NOR test C. asiatica L.; Bdnf; NOR test
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MDPI and ACS Style

Sbrini, G.; Brivio, P.; Fumagalli, M.; Giavarini, F.; Caruso, D.; Racagni, G.; Dell’Agli, M.; Sangiovanni, E.; Calabrese, F. Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients 2020, 12, 355. https://doi.org/10.3390/nu12020355

AMA Style

Sbrini G, Brivio P, Fumagalli M, Giavarini F, Caruso D, Racagni G, Dell’Agli M, Sangiovanni E, Calabrese F. Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients. 2020; 12(2):355. https://doi.org/10.3390/nu12020355

Chicago/Turabian Style

Sbrini, Giulia, Paola Brivio, Marco Fumagalli, Flavio Giavarini, Donatella Caruso, Giorgio Racagni, Mario Dell’Agli, Enrico Sangiovanni, and Francesca Calabrese. 2020. "Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex" Nutrients 12, no. 2: 355. https://doi.org/10.3390/nu12020355

APA Style

Sbrini, G., Brivio, P., Fumagalli, M., Giavarini, F., Caruso, D., Racagni, G., Dell’Agli, M., Sangiovanni, E., & Calabrese, F. (2020). Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients, 12(2), 355. https://doi.org/10.3390/nu12020355

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