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Peer-Review Record

Relationship between Inflammatory Food Consumption and Age-Related Hearing Loss in a Prospective Observational Cohort: Results from the Salus in Apulia Study

Nutrients 2020, 12(2), 426; https://doi.org/10.3390/nu12020426
by Rodolfo Sardone 1,*,†, Luisa Lampignano 1,*,†, Vito Guerra 2, Roberta Zupo 1, Rossella Donghia 2, Fabio Castellana 1, Petronilla Battista 3, Ilaria Bortone 1, Filippo Procino 1, Marco Castellana 1, Andrea Passantino 3, Roberta Rucco 1, Madia Lozupone 4, Davide Seripa 5, Francesco Panza 1, Giovanni De Pergola 6, Gianluigi Giannelli 1, Giancarlo Logroscino 4,7, Heiner Boeing 8 and Nicola Quaranta 9
Reviewer 1:
Reviewer 2: Anonymous
Nutrients 2020, 12(2), 426; https://doi.org/10.3390/nu12020426
Submission received: 15 January 2020 / Revised: 3 February 2020 / Accepted: 5 February 2020 / Published: 7 February 2020
(This article belongs to the Section Nutritional Epidemiology)

Round 1

Reviewer 1 Report

In this manuscript, the authors explored the hypothesis that pro-inflammatory foods  consumption could be associated with age-related hearing loss (ARHL) in a population-based study of elderly subjects in a Mediterranean area. This research topic is meaningful and positive results were obtained. I recommended accepting this article are major revision.

The results clearly proved that pro-inflammatory foods may have negative impacts on ARHL. However, this manuscript did not listed what foods are pro-inflammatory ones and what are not. A comprehensive table should be added to summary the foods involved in this study and classify them into pro-inflammatory and anti-inflammatory classes.

The possible reasons and mechanisms should be descriped why the certain pro-inflammatory foods may cause ARHL.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

In the sentence in lines 207-209, you use the same numbers to describe the difference between normal hearing and AHRL groups. Double check this.

In the discussion/limitations, I would discuss how you would explain why the two populations (GreatAge and MICOL) did not agree on the significance of association of certain variables. (eg. MICOL-3 had a significant association between sugary drinks and ARHL but the GreatAge did not.)

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Most of the concerns have been issued. I recommend accepting this manuscript.

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