Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health?
Abstract
:1. Introduction
2. Vitamin D and Aging
2.1. Vitamin D and Muscle Health: From Bench to Bedside
2.2. Vitamin D Supplements and Muscle Health
2.3. Vitamin D and Cognitive Health: From Bench to Bedside
3. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Criterium | Slowness | Weakness | Low Lean Mass | Summary Definition |
---|---|---|---|---|
International Working Group [7] | Gait speed < 1.0 m/s | Not included | ALM/ht2 ≤ 7.23 kg/m2 | Sarcopenia: slowness and low lean mass |
EWGSOP [8] | Gait speed ≤ 0.8 m/s | Grip strength < 30 kg | ALM/ht2 ≤ 7.23 kg/m2 | (1) Sarcopenia: low lean mass plus slowness or weakness |
(2) Severe sarcopenia: all three criteria | ||||
FNIH Sarcopenia Project primary definition [9] | Gait speed ≤ 0.8 m/s | Grip strength < 26 kg | ALM/body mass index < 0.789 | (1) Weakness and low lean mass |
(2) Slowness with weakness and low lean mass | ||||
Baumgartner [10] | Not included | Not included | ALM/ht2 ≤ 7.23 kg/m2 | Low lean mass |
Newman [11] | Not included | Not included | Residual of actual ALM*-predicted ALM from equation | Low lean mass |
Vitamin D | |||
---|---|---|---|
Source | Deficiency | Insufficiency | Sufficiency |
IOM (2010) [16] | 30 nmol/L | 30–50 nmol/L | 75–250 nmol/L |
U.S Endocrine Society (2011) [17] | 50 nmol/L | 50–75 nmol/L | 75–250 nmol/L |
SIOMMS (2016) [18] | <25 nmol/L | 25–50 nmol/L | 50–80 nmol/L |
AME (2018) [19] | >75 nmol/L in patients at risk of bone disease |
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D’Amelio, P.; Quacquarelli, L. Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health? Nutrients 2020, 12, 628. https://doi.org/10.3390/nu12030628
D’Amelio P, Quacquarelli L. Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health? Nutrients. 2020; 12(3):628. https://doi.org/10.3390/nu12030628
Chicago/Turabian StyleD’Amelio, Patrizia, and Luca Quacquarelli. 2020. "Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health?" Nutrients 12, no. 3: 628. https://doi.org/10.3390/nu12030628