Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates
Abstract
:1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Population A (N = 695) | Population B (N = 894) | |
---|---|---|
Females, n (%) | 342 (49.2) | 492 (55.0) |
Singleton, n (%) | 527 (75.8) | 588 (65.8) |
Gestational Age (week), median (IQR) | 28 (27–29) | 31 (30–33) |
Birth weight (g), mean (SD) | 991 (255) | 1251 (193) |
Birth length (mm), mean (SD) | 356 (30) | 387 (22) |
Head circumference (mm), mean (SD) | 252 (19) | 277 (14) |
Birth weight (SDS), mean (SD) | −0.02 (0.946) | −1.29 (0.845) |
Birth length (SDS), mean (SD) | −0.10 (0.928) | −1.09 (0.976) |
Head circumference (SDS), mean (SD) | −0.06 (1.046) | −1.24 (1.013) |
SGA, n (%) | 76 (10.9) | 459 (51.3) |
LGA, n (%) | 51 (7.3) | 0 (0.0) |
Antenatal steroids, n (%) * | 534 (86.1) | 647 (87.6) |
Population A (N = 695) | Population B (N = 894) | |
---|---|---|
Major morbidities, n (%) | 621(89.4) | 349(39.0) |
Late sepsis, n (%) | 120(17.3) | 34 (1.9) |
NEC, n (%) | 18(2.6) | 17(3.8) |
ROP, n (%) | 44(6.3) | 2(0.2) |
BPD, n (%) | 24(3.5) | 5(0.6) |
RDS, n (%) | 598(86.0) | 299(33.5) |
MV, n (%) * | 568(83.5) | 231(28.9) |
HFOV, n (%) ** | 67(10.9) | 10(1.3) |
IVH, n (%) | 43(7.4) | 6(1.0) |
PVL, n (%) | 32(5.7) | 19(3.2) |
PDA, n (%) | 292(42.0) | 73(8.2) |
Age at discharge in days | ||
median (min-max) | 65 (24–137) | 39 (17–90) |
EUGR Definition | Cross-sectional | Longitudinal | ||||||
---|---|---|---|---|---|---|---|---|
36 Weeks | 40 Weeks | 28 Days | Discharge | 36 Weeks | 40 Weeks | 28 Days | Discharge | |
Study population | ||||||||
non-SGA, n (%) | 489/561 (87.2) | 163/262 (62.2) | 335/572 (58.6) | 565/732 (77.2) | 487/561 (86.8) | 179/262 (68.3) | 390/572 (68.2) | 626/732 (85.5) |
SGA, n (%) | 340/340 (100.0) | 159/167 (95.2) | 250/250 (100.0) | 331/332 (99.7) | 109/340 (32.1) | 90/167 (53.9) | 62/250 (24.8) | 145/332 (43.7) |
Population A | ||||||||
non-SGA, n (%) | 268/331 (81.0) | 107/170 (62.9) | 168/358 (46.9) | 318/447 (71.1) | 312/331 (94.3) | 135/170 (79.4) | 260/358 (72.6) | 414/447 (92.6) |
SGA, n (%) | 47/47 (100.0) | 43/43 (100.0) | 46/46 (100.0) | 49/49 (100.0) | 36/47 (76.6) | 42/43 (97.7) | 11/46 (23.9) | 43/49 (87.8) |
Population B | ||||||||
non-SGA, n (%) | 221/230 (96.1) | 56/92 (60.9) | 167/214 (78.0) | 247/285 (86.7) | 175/230 (76.1) | 44/92 (47.8) | 130/214 (60.8) | 212/285 (74.4) |
SGA, n (%) | 293/293 (100.0) | 116/124 (93.6) | 204/204 (100.0) | 282/283 (99.7) | 73/293 (24.9) | 48/124 (38.7) | 51/204 (25.0) | 102/283 (36.0) |
Study Population | Population A | Population B | |
---|---|---|---|
Weight (g), mean (SD) | 11,146 (1578) | 11,261 (1724) | 11,029 (1406) |
Length (mm), mean (SD) | 853 (39) | 853 (39) | 853 (40) |
Head circumference (mm), mean (SD) | 477 (18) | 477 (19) | 477 (17) |
Weight (SDS), mean (SD) | −1.43 (1.373) | −1.39 (1.492) | −1.47 (1.240) |
Length (SDS), mean (SD) | −0.94 (1.060) | −1.01 (1.057) | −0.86 (1.059) |
Head circumference (SDS), mean (SD) | −0.41 (1.163) | −0.43 (1.231) | −0.39 (1.088) |
TRAIT | EVALUATION | t | EUGR | |||
---|---|---|---|---|---|---|
No | Yes | No vs. Yes | p | |||
WEIGHT | Cross- Sectional | 36 weeks of GA | −0.32 ± 0.192 | −0.67 ± 0.056 | +0.36 ± 0.201 | 0.077 |
40 weeks of GA | −0.57 ± 0.153 | −0.86 ± 0.086 | +0.29 ± 0.180 | 0.110 | ||
28 days | −0.95 ± 0.113 | −0.71 ± 0.065 | −0.24 ± 0.136 | 0.076 | ||
discharge | −0.92 ± 0.121 | −0.65 ± 0.051 | −0.27 ± 0.133 | 0.043 | ||
Longitudinal | 36 weeks of GA | −0.23 ± 0.112 | −0.82 ± 0.067 | +0.59 ± 0.141 | <0.001 | |
40 weeks of GA | −0.47 ± 0.130 | −0.95 ± 0.093 | +0.48 ± 0.166 | 0.004 | ||
28 days | −0.58 ± 0.087 | −0.93 ± 0.074 | +0.36 ± 0.120 | 0.003 | ||
discharge | −0.38 ± 0.099 | −0.80 ± 0.055 | +0.42 ± 0.118 | <0.001 | ||
LENGTH | Cross- Sectional | 36 weeks of GA | −0.09 ± 0.181 | −0.14 ± 0.050 | 0.05 ± 0.189 | 0.772 |
40 weeks of GA | −0.30 ± 0.129 | −0.27 ± 0.073 | −0.02 ± 0.152 | 0.872 | ||
28 days | −0.46 ± 0.103 | −0.19 ± 0.060 | −0.27 ± 0.125 | 0.030 | ||
discharge | −0.61 ± 0.108 | −0.16 ± 0.046 | −0.45 ± 0.120 | <0.001 | ||
Longitudinal | 36 weeks of GA | +0.02 ± 0.100 | −0.21 ± 0.061 | +0.23 ± 0.126 | 0.072 | |
40 weeks of GA | −0.11 ± 0.107 | −0.38 ± 0.079 | +0.27 ± 0.137 | 0.053 | ||
28 days | −0.18 ± 0.078 | −0.33 ± 0.069 | +0.15 ± 0.109 | 0.180 | ||
discharge | −0.11 ± 0.089 | −0.29 ± 0.051 | +0.18 ± 0.107 | 0.094 | ||
HEAD CIRCUMFERENCE | Cross- Sectional | 36 weeks of GA | +0.31 ± 0.159 | +0.33 ± 0.046 | −0.02 ± 0.167 | 0.924 |
40 weeks of GA | +0.20 ± 0.126 | +0.22 ± 0.071 | −0.01 ± 0.148 | 0.939 | ||
28 days | −0.01 ± 0.094 | +0.22 ± 0.053 | −0.23 ± 0.113 | 0.045 | ||
discharge | +0.07 ± 0.104 | +0.32 ± 0.043 | −0.25 ± 0.114 | 0.029 | ||
Longitudinal | 36 weeks of GA | +0.64 ± 0.092 | +0.20 ± 0.055 | +0.44 ± 0.115 | <0.001 | |
40 weeks of GA | +0.34 ± 0.108 | +0.15 ± 0.077 | +0.20 ± 0.138 | 0.156 | ||
28 days | +0.33 ± 0.072 | +0.03 ± 0.061 | +0.30 ± 0.100 | 0.003 | ||
nidischarge | +0.52 ± 0.084 | +0.20 ± 0.047 | +0.32 ± 0.100 | 0.001 |
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Peila, C.; Spada, E.; Giuliani, F.; Maiocco, G.; Raia, M.; Cresi, F.; Bertino, E.; Coscia, A. Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates. Nutrients 2020, 12, 1224. https://doi.org/10.3390/nu12051224
Peila C, Spada E, Giuliani F, Maiocco G, Raia M, Cresi F, Bertino E, Coscia A. Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates. Nutrients. 2020; 12(5):1224. https://doi.org/10.3390/nu12051224
Chicago/Turabian StylePeila, Chiara, Elena Spada, Francesca Giuliani, Giulia Maiocco, Melissa Raia, Francesco Cresi, Enrico Bertino, and Alessandra Coscia. 2020. "Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates" Nutrients 12, no. 5: 1224. https://doi.org/10.3390/nu12051224