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Review
Peer-Review Record

Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies

Nutrients 2021, 13(10), 3492; https://doi.org/10.3390/nu13103492
by Martina Lombardi 1,2 and Jacopo Troisi 1,2,*
Reviewer 2: Anonymous
Nutrients 2021, 13(10), 3492; https://doi.org/10.3390/nu13103492
Submission received: 9 September 2021 / Revised: 27 September 2021 / Accepted: 29 September 2021 / Published: 2 October 2021
(This article belongs to the Special Issue Microbiome, Probiotics and Autism: Where Do We Stand?)

Round 1

Reviewer 1 Report

The authors have done an excellent job on both the articles reviewed, but also the gaps that remain in the literature. This paper serves to create a translational bridge between Pediatrics, Neurology, Gastroenterology, and Microbiology. This relationship will only be made stronger by thoughtful systematic analysis. 

I found two typographical errors for editors to correct:

Line 439: multiple space gap between of and it

Line 449: genetic and effects should be separated

Author Response

We are thankful to the reviewer for the comment and the useful improve suggests. We provided a new MS version accounting for all the suggested improvements.

Reviewer 2 Report

Dear Authors,

The Editors of Nutrients have kindly invited me to review of your manuscript. Please find my comments below: 

  • The title should go "How far are we", as this is a question. 
  • Line 37: "Nowadays, different types of autism are considered" (not "autisms").
  • Line 67: Please correct typo. "intimate relationship". 
  • Section 2. Materials and methods. Great section. 
  • Section 3. Gut microbiome modification and ASD. Beautifully written providing excellent insights from the literature review. 
  • Figure 2: I would recommend using "Intestinal permeability (leaky gut)" in the right section of the diagram. 
  • Section 4 should be a "Discussion", with 4.1 being "Perspectives from ongoing investigations", and 4.2 a brief conclusion (no more than 15-20 lines).

 

I hope you find my comments useful in the review process of your manuscript, which I have found most enlightening. If you were able to weave in my recommendations, I should be only too happy to recommend that your review be accepted for publication. 

Kind regards,

The reviewer 

Author Response

We are thankful to the reviewer for the comment and the useful improve suggests. We provided a new MS version accounting for all the suggested improvements.

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