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Volume 13
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10.3390/nu13103652
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Article

Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model

by
Meng-Chun Lu
1,2,3,
I-Te Lee
4,
Ling-Zong Hong
5,
Eyal Ben-Arie
6,
Yu-Hsuan Lin
3,
Wei-Ting Lin
3,
Pei-Yu Kao
7,
Mei-Due Yang
8 and
Yin-Ching Chan
3,*
1
Department of Clinical Nutrition, China Medical University Hospital, Taichung 406040, Taiwan
2
Department of Nutrition, China Medical University, Taichung 406040, Taiwan
3
Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan
4
Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung 40705, Taiwan
5
Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
6
Graduate Institute of Acupuncture Science, Collage of Chinese Medicine, China Medical University, Taichung 406040, Taiwan
7
Division of Thoracic Surgery, Department of Surgery, China Medical University Hospital, Taichung 406040, Taiwan
8
Division of General Surgery, Department of Surgery, China Medical University Hospital, Taichung 406040, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(10), 3652; https://doi.org/10.3390/nu13103652
Submission received: 3 September 2021 / Revised: 12 October 2021 / Accepted: 13 October 2021 / Published: 19 October 2021
(This article belongs to the Section Nutrition and Metabolism)
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Abstract

Nonalcoholic fatty liver disease (NAFLD) shows extensive liver cell destruction with lipid accumulation, which is frequently accompanied by metabolic comorbidities and increases mortality. This study aimed to investigate the effects of coffeeberry (CB) on regulating the redox status, the CaMKII/CREB/BDNF pathway, autophagy, and apoptosis signaling by a NAFLD rodent model senescence-accelerated mice prone 8 (SAMP8). Three-month-old male SAMP8 mice were divided into a control group and three CB groups (50, 100, and 200 mg/kg BW), and fed for 12 weeks. The results show that CB reduced hepatic malondialdehyde and carbonyl protein levels. CB significantly enhanced Ca2+/calmodulin-dependent protein kinase II (CaMKII) and brain-derived neurotrophic factor (BDNF) and reduced the phospho-cAMP response element-binding protein (p-CREB)/CREB ratio. In addition, CB increased the silent information regulator T1 level, promoted Beclin 1 and microtubule-associated protein light chain 3 II expressions, and reduced phosphorylated mammalian target of rapamycin and its downstream p-p70s6k levels. CB also inhibited the expressions of apoptosis-related factors poly (ADP-ribose) polymerase-1 and the apoptosis-inducing factor. In conclusion, CB might protect the liver by reducing oxidative stress, activating the CaMKII/CREB/BDNF pathway, and improving autophagic and apoptotic expressions in a dose-dependent manner.
Keywords: nonalcoholic fatty liver disease; coffeeberry; redox status; CaMKII/CREB/BDNF; autophagy; apoptosis nonalcoholic fatty liver disease; coffeeberry; redox status; CaMKII/CREB/BDNF; autophagy; apoptosis

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MDPI and ACS Style

Lu, M.-C.; Lee, I.-T.; Hong, L.-Z.; Ben-Arie, E.; Lin, Y.-H.; Lin, W.-T.; Kao, P.-Y.; Yang, M.-D.; Chan, Y.-C. Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model. Nutrients 2021, 13, 3652. https://doi.org/10.3390/nu13103652

AMA Style

Lu M-C, Lee I-T, Hong L-Z, Ben-Arie E, Lin Y-H, Lin W-T, Kao P-Y, Yang M-D, Chan Y-C. Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model. Nutrients. 2021; 13(10):3652. https://doi.org/10.3390/nu13103652

Chicago/Turabian Style

Lu, Meng-Chun, I-Te Lee, Ling-Zong Hong, Eyal Ben-Arie, Yu-Hsuan Lin, Wei-Ting Lin, Pei-Yu Kao, Mei-Due Yang, and Yin-Ching Chan. 2021. "Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model" Nutrients 13, no. 10: 3652. https://doi.org/10.3390/nu13103652

APA Style

Lu, M.-C., Lee, I.-T., Hong, L.-Z., Ben-Arie, E., Lin, Y.-H., Lin, W.-T., Kao, P.-Y., Yang, M.-D., & Chan, Y.-C. (2021). Coffeeberry Activates the CaMKII/CREB/BDNF Pathway, Normalizes Autophagy and Apoptosis Signaling in Nonalcoholic Fatty Liver Rodent Model. Nutrients, 13(10), 3652. https://doi.org/10.3390/nu13103652

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