Influence of the Bioactive Diet Components on the Gene Expression Regulation

Mierziak, Justyna; Kostyn, Kamil; Boba, Aleksandra; Czemplik, Magdalena; Kulma, Anna; Wojtasik, Wioleta

doi:10.3390/nu13113673

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Influence of the Bioactive Diet Components on the Gene Expression Regulation

by

Justyna Mierziak

^1,*,

Kamil Kostyn

²

,

Aleksandra Boba

¹

,

Magdalena Czemplik

¹,

Anna Kulma

¹

and

Wioleta Wojtasik

^1,*

¹

Faculty of Biotechnology, University of Wrocław, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland

²

Department of Genetics, Plant Breeding & Seed Production, Faculty of Life Sciences and Technology, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 24A, 50-363 Wroclaw, Poland

^*

Authors to whom correspondence should be addressed.

Nutrients 2021, 13(11), 3673; https://doi.org/10.3390/nu13113673

Submission received: 10 September 2021 / Revised: 13 October 2021 / Accepted: 14 October 2021 / Published: 20 October 2021

(This article belongs to the Special Issue Gene Expression Changes and Variability in Response to Dietary Bioactives: Molecular Mechanisms Associated with Disease Prevention?)

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Abstract

Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food constituents, which can transfer information from the external environment and influence gene expression in the cell and thus the function of the whole organism. It is crucial to regard food not only as the source of energy and basic nutriments, crucial for living and organism development, but also as the factor influencing health/disease, biochemical mechanisms, and activation of biochemical pathways. Bioactive components of the diet regulate gene expression through changes in the chromatin structure (including DNA methylation and histone modification), non-coding RNA, activation of transcription factors by signalling cascades, or direct ligand binding to the nuclear receptors. Analysis of interactions between diet components and human genome structure and gene activity is a modern approach that will help to better understand these relations and will allow designing dietary guidances, which can help maintain good health.

Keywords: bioactive diet components; gene expression; DNA methylation; histone modification; non-coding RNA; signalling cascades; nuclear receptor

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MDPI and ACS Style

Mierziak, J.; Kostyn, K.; Boba, A.; Czemplik, M.; Kulma, A.; Wojtasik, W. Influence of the Bioactive Diet Components on the Gene Expression Regulation. Nutrients 2021, 13, 3673. https://doi.org/10.3390/nu13113673

AMA Style

Mierziak J, Kostyn K, Boba A, Czemplik M, Kulma A, Wojtasik W. Influence of the Bioactive Diet Components on the Gene Expression Regulation. Nutrients. 2021; 13(11):3673. https://doi.org/10.3390/nu13113673

Chicago/Turabian Style

Mierziak, Justyna, Kamil Kostyn, Aleksandra Boba, Magdalena Czemplik, Anna Kulma, and Wioleta Wojtasik. 2021. "Influence of the Bioactive Diet Components on the Gene Expression Regulation" Nutrients 13, no. 11: 3673. https://doi.org/10.3390/nu13113673

APA Style

Mierziak, J., Kostyn, K., Boba, A., Czemplik, M., Kulma, A., & Wojtasik, W. (2021). Influence of the Bioactive Diet Components on the Gene Expression Regulation. Nutrients, 13(11), 3673. https://doi.org/10.3390/nu13113673

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Influence of the Bioactive Diet Components on the Gene Expression Regulation

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