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Volume 13
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10.3390/nu13113921
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Article

Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

by
Chang-Mu Chen
1,
Chen-Yu Lin
2,
Yao-Pang Chung
2,
Chia-Hung Liu
3,4,5,
Kuo-Tong Huang
6,
Siao-Syun Guan
7,
Cheng-Tien Wu
8,9,* and
Shing-Hwa Liu
2,10,11,*
1
Division of Neurosurgery, Department of Surgery, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan
2
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
3
Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11041, Taiwan
4
TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei 11041, Taiwan
5
Department of Urology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
6
Department of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan
7
Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan 32546, Taiwan
8
Department of Nutrition, China Medical University, Taichung 406040, Taiwan
9
Master Program of Food and Drug Safety, China Medical University, Taichung 406040, Taiwan
10
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 406040, Taiwan
11
Department of Paediatrics, National Taiwan University Hospital, Taipei 10051, Taiwan
 
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Authors to whom correspondence should be addressed.
Nutrients 2021, 13(11), 3921; https://doi.org/10.3390/nu13113921
Submission received: 17 September 2021 / Revised: 28 October 2021 / Accepted: 29 October 2021 / Published: 1 November 2021
(This article belongs to the Section Nutrition and Public Health)
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Abstract

Nootkatone is one of the major active ingredients of Alpiniae oxyphyllae, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.
Keywords: chronic kidney disease; nootkatone; inflammation; apoptosis; renal fibrosis chronic kidney disease; nootkatone; inflammation; apoptosis; renal fibrosis

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MDPI and ACS Style

Chen, C.-M.; Lin, C.-Y.; Chung, Y.-P.; Liu, C.-H.; Huang, K.-T.; Guan, S.-S.; Wu, C.-T.; Liu, S.-H. Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model. Nutrients 2021, 13, 3921. https://doi.org/10.3390/nu13113921

AMA Style

Chen C-M, Lin C-Y, Chung Y-P, Liu C-H, Huang K-T, Guan S-S, Wu C-T, Liu S-H. Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model. Nutrients. 2021; 13(11):3921. https://doi.org/10.3390/nu13113921

Chicago/Turabian Style

Chen, Chang-Mu, Chen-Yu Lin, Yao-Pang Chung, Chia-Hung Liu, Kuo-Tong Huang, Siao-Syun Guan, Cheng-Tien Wu, and Shing-Hwa Liu. 2021. "Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model" Nutrients 13, no. 11: 3921. https://doi.org/10.3390/nu13113921

APA Style

Chen, C.-M., Lin, C.-Y., Chung, Y.-P., Liu, C.-H., Huang, K.-T., Guan, S.-S., Wu, C.-T., & Liu, S.-H. (2021). Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model. Nutrients, 13(11), 3921. https://doi.org/10.3390/nu13113921

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