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Article
Peer-Review Record

Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial

Nutrients 2021, 13(11), 4095; https://doi.org/10.3390/nu13114095
by Max L. Eckstein 1, Antonia Brockfeld 1, Sandra Haupt 1, Janis R. Schierbauer 1, Rebecca T. Zimmer 1, Nadine Wachsmuth 1, Beate Zunner 1, Paul Zimmermann 1, Barbara Obermayer-Pietsch 2 and Othmar Moser 1,3,*
Reviewer 1: Anonymous
Reviewer 2:
Nutrients 2021, 13(11), 4095; https://doi.org/10.3390/nu13114095
Submission received: 27 October 2021 / Revised: 11 November 2021 / Accepted: 13 November 2021 / Published: 16 November 2021
(This article belongs to the Special Issue Endocrinology, Metabolic Diseases and Nutrition)

Round 1

Reviewer 1 Report

General comment

In its simplicity the experiment is interesting and useful. The method is correct, the same for the analysis. The weakness is in the discussion: results are debated in healthy, in diabetes and in athletes, but there aren’t enough elements for deductions so enlarged. It would be better to concentrate only in the kind of enrolled population.

Author Response

Please see attachment

Author Response File: Author Response.docx

Reviewer 2 Report

The reviewer acknowledge the authors for this manuscript and supports that a good description of the scope of the study as well as a good bibliography search was performed. the authors have evaluated important para meters for the problematic of sugar supplementing in healthy people going or not for exercise. minor corrections must be made:

Introduction line 37: type 2 diabetes is missing in the sentence "type 1- (T1DM) and mellitus (T2DM)"

Materials and methods line 116 the abbreviations have been already described previously in the section

results line 166: "blood glucose" was already described and abbreviated as BG previously in the text

Author Response

Please see attachment

Author Response File: Author Response.docx

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