Differing Nutrient Intake and Dietary Patterns According to the Presence of Hyper-Low-Density Lipoprotein Cholesterolemia or Hypertriglyceridemia

Round 1

Reviewer 1 Report

By analyzing data from the KNHANES, the authors studied the correlation between nutrient intake (e.g. fat, carb, and breakfast) and CVD lipid risks with a PS matched statistical analysis. They show that high fat% intake was associated with high LDL-C levels and high carb% intake was associated with high TG levels.  They also showed the correlation between missing breakfast and high TG levels, and the Na/K ratio in food intake in hLDL and hTG populations. This study is of interest to Nutrients’s readers.

 

Comments:

1. In the section of 2.4 Assessment of nutrition intake and dietary patterns (2^nd paragraph): It is not yet clear to show how the authors calculated the scores for Milk, breakfast, SFA, etc.  More detailed information is required. For example, what does it mean for a participant who had a Milk score of 3?  Also in Figure 2, the summary for percentages of score ≤ 3, 4 ≤ score ≤ 6 and 7 ≤ score, was 100%, does it mean that no participant’s score fell somewhere between 3 and 4, or between 6 and 7?  If so, why?
2. The history of nutrition intake (e.g. 3 months or 5 years) should be presented if possible because the information would be helpful to better study the correlation between nutrient intake and CVD risks.
3. According to Table 2, the hLDL group has a higher fat% intake associated with a higher % SFA and PUFA intake. However, in Figure 2A the lower panel, the % for SFA score ³7 was lower in the hLDL group than the non-hLDL group (63.92% vs 68.58). How could the authors explain this paradox?
4. In the Discussion (line 247-248): when the authors discussed the benefit of omega-3 intake for lipid profile, the total energy intake must be considered and discussed.
5. I noticed that the Na intake in all groups in this study was higher than 2g/day. Thus the high Na intake in this study should be included In the Discussion.

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Undoubtedly high-quality article on a very prevalent topic of great importance for cardiovascular risk, due to the fact that high levels of LDL cholesterol and triglycerides are associated with a lower incidence of cardiovascular events.

It is a study with an adequate introduction, material and correctly planned method, highlighting a very high number of subjects included (24,269). The results are clearly expressed despite being very numerous and the discussion is adequate. A healthy diet is associated with lower levels of HDL cholesterol.

In summary, it seems to me a quality article that contributes a lot.

Author Response

I appreciate your careful review of our manuscript and the constructive comments.
It was a great honor to me to discuss this topic with you.