Exercise-Induced Hyperhomocysteinemia Is Not Related to Oxidative Damage or Impaired Vascular Function in Amateur Middle-Aged Runners under Controlled Nutritional Intake
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Experimental Design
2.3. Baseline Evaluation
2.4. Dietary Control
2.5. Blood Sampling
2.6. Biochemical Determinations
2.6.1. Homocysteine and Vitamins
2.6.2. Oxidative Stress
2.6.3. Endothelial Function
2.7. Statistical Analysis
3. Results
3.1. Physical Characteristics and Training Profile
3.2. tHcy Kinetics
3.3. Oxidative Status
3.4. Endothelial Function
3.5. Vitamin Levels and Dietary Intake
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Plasma Vitamin Concentration | Timepoint | 10K | M |
---|---|---|---|
Vitamin B12 (pmol/L) | Basal | 500.5 ± 86.1 1,a | 527.1 ± 75.5 1,a,b |
Post0 | 547.1 ± 106.7 2,a | 584.2 ± 74.1 2,a,b | |
Post24 | 472.0 ± 99.5 3 | 477.4 ± 72.1 3 | |
Vitamin B6 (nmol/L) | Basal | 84.7 ± 52.9 | 111.4 ± 70.3 |
Post0 | 70.2 ± 36.5 | 66.1 ± 25.9 | |
Post24 | 63.6 ± 28.3 | 95.9 ± 56.0 | |
Folate (nmol/L) | Basal | 7.6 ± 1.9 1,a | 10.9 ± 3.4 1,b |
Post0 | 10.1 ± 3.0 2,3 | 11.2 ± 2.8 1,2 | |
Post24 | 8.1 ± 2.7 1 | 8.9 ± 2.3.2 |
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Iglesias-Gutiérrez, E.; García-González, Á.; Montero-Bravo, A.; González-Medina, A.; Joglar, J.; Tomás-Zapico, C.; Fernández-García, B.; Fernández-Sanjurjo, M.; de Gonzalo-Calvo, D.; Díaz-Martínez, Á.E.; et al. Exercise-Induced Hyperhomocysteinemia Is Not Related to Oxidative Damage or Impaired Vascular Function in Amateur Middle-Aged Runners under Controlled Nutritional Intake. Nutrients 2021, 13, 3033. https://doi.org/10.3390/nu13093033
Iglesias-Gutiérrez E, García-González Á, Montero-Bravo A, González-Medina A, Joglar J, Tomás-Zapico C, Fernández-García B, Fernández-Sanjurjo M, de Gonzalo-Calvo D, Díaz-Martínez ÁE, et al. Exercise-Induced Hyperhomocysteinemia Is Not Related to Oxidative Damage or Impaired Vascular Function in Amateur Middle-Aged Runners under Controlled Nutritional Intake. Nutrients. 2021; 13(9):3033. https://doi.org/10.3390/nu13093033
Chicago/Turabian StyleIglesias-Gutiérrez, Eduardo, Ángela García-González, Ana Montero-Bravo, Antonio González-Medina, Judit Joglar, Cristina Tomás-Zapico, Benjamín Fernández-García, Manuel Fernández-Sanjurjo, David de Gonzalo-Calvo, Ángel Enrique Díaz-Martínez, and et al. 2021. "Exercise-Induced Hyperhomocysteinemia Is Not Related to Oxidative Damage or Impaired Vascular Function in Amateur Middle-Aged Runners under Controlled Nutritional Intake" Nutrients 13, no. 9: 3033. https://doi.org/10.3390/nu13093033