Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment
Abstract
:1. Introduction
2. What Is a cAMP?
3. Pancreas
3.1. cAMP Signaling Pathway
3.2. The Dietary Bioactive Ingredients Targeting Pancreas cAMP Signaling for Glucose Homeostasis
4. Liver
4.1. cAMP Signaling Pathway
4.2. The Dietary Bioactive Ingredients Targeting Liver cAMP Signaling for Glucose Homeostasis
5. Gut
5.1. cAMP Signaling Pathway
5.2. The Dietary Bioactive Ingredients Targeting Gut cAMP Signaling for Glucose Homeostasis
6. Skeletal Muscle
6.1. cAMP Signaling Pathway
6.2. The Dietary Bioactive Ingredients Targeting Skeletal Muscle cAMP Signaling for Glucose Homeostasis
7. Adipose Tissue
7.1. cAMP Signaling Pathway
7.2. The Dietary Bioactive Ingredients Targeting Adipose Tissue cAMP Signaling for Glucose Homeostasis
8. Brain
9. Kidney
10. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Compounds | Main Source of Food | Concentration of cAMP | Main Effect | Mechanism of Action | Model | Refs. |
---|---|---|---|---|---|---|
Resveratrol | Peanut; grape (red wine); mulberry | • ↑ cAMP | • ↓ Blood glucose • ↑ Insulin sensitivity | • Inhibition of PDE activity | • MIN6 cells • HP62 cells | [43] |
• ↑ cAMP | • ↑ Insulin secretion | • Activation of cAMP/Epac1signaling pathway | • C57BL/6N mice | [44] | ||
[6]-Gingerol | Ginger | • ↑ cAMP | • ↑ Insulin secretion | • Activation of cAMP/PKA signaling pathway | • db/db mice | [45] |
Curcumin | Ginger | • ↑ cAMP | • ↑ Insulin sensitivity | • Inhibition of PDE activity | • MIN6 cells • HP62 cells | [43] |
Genistein | Soy; locust horn | • ↑ cAMP | • ↑ Pancreatic β-cell proliferation | • Activation of cAMP/PKA MEK/ERK signaling • Phosphorylation of ERK1/2 | • INS-1 cells • PANC1s cells | [36] |
• ↑ cAMP | • ↑ Insulin secretion | • Activation of the Adcy/cAMP/PKA signaling pathway | • INS-1 cells • MIN6 cells | [18] | ||
• ↑ cAMP | • ↑ Insulin secretion | • Accumulation of cAMP and Ca2+ | • MIN6 cells | [46] | ||
• ↑ cAMP | • ↓ Hyperglycemia • ↑ Glucose tolerance | • Improvement of islet β-cell proliferation, survival, and mass | • C57BL/6J mice | [36] | ||
7WA | Green tea | • ↑ cAMP | • ↑ Insulin secretion | • Activation of cAMP/PKA signaling pathway | • RIN-5F cells | [47] |
Fucoidan | Seaweed Fucus vesiculosus | • ↑ cAMP | • ↑ Insulin secretion • ↓ Hyperglycemia • ↑ Pancreatic β-cell proliferation | • Activation of cAMP/PKA and PI3K/Akt signaling pathway | • INS-1E cells • Human islets | [48] |
Oleanolic acid | Jujube; papaya | • ↑ cAMP | • ↑ Insulin secretion | • Activation Gs/cAMP/Ca2+ signaling pathway | • MIN6 cells | [49] |
Coixol | Coix chinensis | • ↑ cAMP | • ↑ Insulin secretion | • Activation of cAMP/PKA signaling pathway | • MIN6 cells | [50] |
Compounds | Main Source of Food | Concentration of cAMP | Main Effect | Mechanism of Action | Model | Refs. |
---|---|---|---|---|---|---|
Curcumin | Ginger | • ↓ cAMP | • ↓ Hepatic glucose production | • Preservation of PDE4B activity • Inhibition of acetyl CoA production | • ICR mice • Primary hepatocytes • HepG2 cells | [19] |
Ginsenoside Rg5 | Ginseng | • ↓ cAMP | • ↓ Hepatic gluconeogenesis | • Preservation of PDE4B activity | • C57BL/6J mice • Primary hepatocytes | [59] |
Phanginin A | Caesalpinia sappan | • ↓ cAMP | • ↓ Hepatic gluconeogenesis | • Activation of PDE4 activity • Inhibition of cAMP/PKA/CREB signaling pathway | • C57BL/6J mice • Primary hepatocytes | [15] |
Astragaloside IV | Astragalus membranaceus | • ↓ cAMP | • ↓ Hepatic lipid deposition • ↓ Hepatic glucose production | • Preservation of PDE3B activity | • ICR mice | [60] |
Berberine | Cortex phellodendri; coptis chinensis | • ↓ cAMP | • ↓ Hepatic gluconeogenesis | • Activation of PDE activity | • ob/ob mice | [61] |
• ↓ cAMP | • ↓ Hepatic gluconeogenesis | • Inhibition of glucagon signaling | • Primary hepatocytes | |||
Ginsenoside Rb1 | Ginseng | • ↓ cAMP | • ↓ Hepatic gluconeogenesis | • Inhibition of Adcy activity • Inactivation of CREB | • C57BL/6J mice • Primary hepatocytes | [62] |
Dendrobium officinale polysaccharide | Dendrobium officinale | • ↓ cAMP | • ↑ Hepatic glycogen synthesis • ↓ Hepatic glycogen degradation • ↓ Hepatic gluconeogenesis | • Inactivation of Adcy activity • Reduction the expression of PKA | • C57BL/6J mice | [63] |
Epigallocatechin gallate | Green tea | ND | • ↓ Hepatic glucose production | • Inhibition of cAMP/PKA/CREB signaling pathway | • Primary hepatocytes | [64] |
Compounds | Main Source of Food | Concentration of cAMP | Main Effect | Mechanism of Action | Model | Refs. |
---|---|---|---|---|---|---|
Coffee polyphenols | Coffee, goji berries | • ↑ cAMP | • ↑ GLP-1 secretion | • Activation of cAMP-dependent pathway | • NCI-H716 cells | [69] |
Geraniol | Geranium; lemon | • ↑ cAMP | • ↑ GLP-1 secretion | • Activation of OR1G1 /cAMP/PKA signaling pathway | • NCI-H716 cells | [70] |
Citronellal | Kaffir lime leaves | • ↑ cAMP | • ↑ GLP-1 secretion | • Activation of OR1G1/cAMP/PKA signaling pathway | • NCI-H716 cells | [70] |
Delphinidin | Bilberry; Maqui berry | • ↑ cAMP | • ↓ Glucose uptake | • Activation of FFA1/GPR40/cAMP signaling pathway | • RF/J mice • HT-29 cells • Caco-2 cells • NCM460 cells | [71] |
Resveratrol | Peanut; grape (red wine); mulberry | • ↑ cAMP | • ↓ Glucose and alanine transport | • Inhibition of PDE activity | • Porcine jejunum and ileum | [72] |
Polygonatum cyrtonema polysaccharide | Polygonatum cyrtonema | • ↑ cAMP | • ↑ GLP-1 secretion | • Activation of the T1R2/T1R3/cAMP signaling pathway | • NCI-H716 cells | [73] |
Anthraquinone-glycoside | Rhubarb | • ↑ cAMP | • ↑ GLP-1 secretion | • Activation of cAMP signaling pathway | • SD rats | [74] |
Oleanolic acid | Jujube; Papaya | • ↑ cAMP | • ↑ GLP-1 and PYY secretion | • Activation of TGR5/cAMP/Epac/Ca2+ signaling pathway | • STC-1 cells | [75] |
Oleanolic acid derivative DKS26 | Hawthorn | • ↑ cAMP | • ↑ GLP-1 secretion | • Activation of the cAMP/PKA signaling pathway | • db/db mice • NCI-H716 cells | [76] |
Nonanoic Acid | Royal jelly | • ↑ cAMP | • ↑ GLP-1 and PYY secretion | • Activation of OR51E1/cAMP and p-ERK signaling pathway | • SD rats • NCI-H716 cells | [77] |
Butyrate | Cheese | • ↑ cAMP | • ↑ Insulin sensitivity | • Activation of cAMP dependent pathway | • SD rats • Caco-2 cells | [68] |
Compounds | Main Source of Food | Concentration of cAMP | Main Effect | Mechanism | Model | Refs. |
---|---|---|---|---|---|---|
Daidzein | Soy; celery | • ↑ cAMP | • ↑ Glucose uptake | • Inhibition of PDE4 activity • Improved the AMPK phosphorylation | • L6 cells • db/db mice | [87] |
Cyanidin-3-O-β-glucoside | Black soybean; blueberry | • ↑ cAMP | • ↑ Exercise performance | • Inhibition of PDE activity | • ICR mice • C2C12 cells | [88] |
α-Cedrene | Cedar wood oil | • ↑ cAMP | • ↑ Glucose uptake | • Activation of OR23/cAMP/PKA signaling pathway | • C2C12 cells | [89] |
[6]-Gingerol | Ginger | • ↑ cAMP | • ↑ Glycogen deposition | • Activation of cAMP/PKA/CREB signaling pathway | • db/db mice | [45] |
Resveratrol | Grape; mulberry | • ↑ cAMP | • ↑ Glucose uptake | • Inhibition of PDE4 activity | • C2C12 cells | [19,90] |
Genistein | Soy | • ↑ cAMP | • ↑ Glucose uptake | • Inhibition of PDE activity | • L6 cells | [91] |
Oleic acid | Walnuts; nuts; almonds | • ↑ cAMP | • ↑ Oxidation of fatty acids | • Activation of Sirtin1-PGC1α complex | • C57BL/6 mice | [64,92] |
• ↑ cAMP | • ↑ Insulin sensitivity | / | • Wistar rats | [93] |
Compounds | Main Source of Food | Concentration of cAMP | Main Effect | Mechanism of Action | Model | Refs. |
---|---|---|---|---|---|---|
α-Cedrene | Cedar wood oil | • ↑ cAMP | • ↑ Glucose uptake | • Stimulation of mOR23/cAMP/PKA signaling pathway | • 3T3-L1 adipocytes | [89] |
Pachymic acid | Poria cocos | • ↓ cAMP | • ↑ Glucose uptake • ↓ Lipolysis | • Stimulation of GLUT4 expression and redistribution | • 3T3-L1 adipocytes | [102] |
Curcumin | Ginger | • ↓ cAMP | • ↓ Lipolysis | • Reduction of ER stress | • C57BL/6 mice • 3T3-L1 adipocytes | [103] |
Ginsenoside Rg5 | Ginseng | • ↓ cAMP | • ↓ Lipolysis • ↑ Insulin resistance | • Preservation of PDE3B activity | • 3T3-L1 adipocytes | [104] |
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Wang, Y.; Liu, Q.; Kang, S.-G.; Huang, K.; Tong, T. Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment. Nutrients 2021, 13, 3038. https://doi.org/10.3390/nu13093038
Wang Y, Liu Q, Kang S-G, Huang K, Tong T. Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment. Nutrients. 2021; 13(9):3038. https://doi.org/10.3390/nu13093038
Chicago/Turabian StyleWang, Yanan, Qing Liu, Seong-Gook Kang, Kunlun Huang, and Tao Tong. 2021. "Dietary Bioactive Ingredients Modulating the cAMP Signaling in Diabetes Treatment" Nutrients 13, no. 9: 3038. https://doi.org/10.3390/nu13093038