Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Protocol
2.2. Eligibility Criteria
2.3. Information Sources and Search
2.4. Study Selection
2.5. Data Collection Process
2.6. Definitions for Data Extraction
2.7. Risk of Bias and Applicability
2.8. Diagnostic Accuracy Measures
2.9. Meta-Analysis
3. Results
3.1. Study Selection
3.2. Study Characteristics
3.3. Results of Individual Studies
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Publication | Study Type and Location | Total No. Included | Gender (%Female) | Age | Population | Target Condition | Reference Test | Index Tests | TP | TN | TP DGP IgG | TP TTG IgA | TN DGP IgG | TN TTG IgA |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parizade 2010 [15] | Prospective controlled, Israel | 5002 | NR | <2 yr | 200 symptomatic children; 4802 healthy children | CD | Intestinal biopsy | DGP IgG and TTG IgA | 41 | 4961 | 41/41 | 35/41 | 4912/4961 | 4961/4961 |
Barbato 2011 [16] | Prospective controlled, Italy | 80 | 43 | 4–24 mo | 40 children with classic symptoms of CD and with DGP IgG positive and TTG IgA negative; 40 healthy children | CD | Intestinal biopsy | DGP IgG and TTG IgA | 11 | 69 | 11/11 | 0/11 | 69/69 | 69/69 |
Monzani 2011 [17] | Prospective, controlled, Italy | 130 | NR | <2 yr | 24 children with classic symptoms of CD; 106 healthy children | CD | Intestinal biopsy | DGP IgG and TTG IgA | 24 | 106 | 24/24 | 24/24 | NR | NR |
Amarri 2013 [18] | Prospective controlled, Italy | 57 | 62 | <2 yr | 34 children with classic symptoms of CD; 23 healthy children | CD | Intestinal biopsy | DGP IgG and TTG IgA | 34 | 23 | 34/34 | 33/34 | 23/23 | 23/23 |
Oyaert 2015 [19] | Prospective controlled, Belgium | 210 | 44 | <2 yr | 13 symptomatic children; 197 healthy children | CD | Intestinal biopsy | DGP IgG and TTG IgA | 13 | 197 | 13/13 | 12/13 | 191/197 | 196/197 |
Basso 2008 [20] | Retrospective, Italy | 46 | NR | <2 yr | 46 symptomatic children undergoing intestinal biopsy | CD | Intestinal biopsy | DGP IgG and TTG IgA | 30 | 16 | 29/30 | 29/30 | 16/16 | 16/16 |
Mubarak 2011 [21] | Retrospective, The Netherlands | 41 | NR | <2 yr | 41 symptomatic children undergoing intestinal biopsy | CD | Intestinal biopsy | DGP IgG and TTG IgA | 26 | 15 | 26/26 | 25/26 | 15/15 | 15/15 |
Olen 2012 [22] | Retrospective, Sweden | 71 | NR | <2 yr | 71 symptomatic children undergoing intestinal biopsy | CD | Intestinal biopsy | 65 children tested for DGP IgG and TTG IgA; 2 tested for TTG IgA only; 4 tested for DGP IgG only) | 26 (24 tested for both index tests; 2 tested only for TTG IgA). | 45 (41 tested for both index tests; 4 tested only for DGP IgG) | 24/24 | 24/26 | 14/45 | 40/41 |
Frulio 2015 [23] | Retrospective, Italy | 348 | 49 | 6–24 yr | 348 symptomatic children undergoing intestinal biopsy | CD | Intestinal biopsy | DGP IgG and TTG IgA | 21 | 327 | 19/21 | 21/21 | 312/327 | 327/327 |
Hojsak 2012 [24] | Retrospective, Israel | 31 | 46 | <2 yr | 31 symptomatic children undergoing intestinal biopsy | CD | Intestinal biopsy | DGP IgG and TTG IgA | 31 | NR | 31/31 | 30/30 | NR | NR |
Catassi 2020 [25] | Case report, Italy | 1 | 100 | 18 mo | 1 child presenting with CD crisis | CD | Intestinal biopsy | DGP IgG and TTG IgA | 1 | NA | 1/1 | 0 | NA | NA |
Arigliani 2017 [26] | Case report, Italy | 1 | 0 | 8 mo | 1 child presenting with failure to thrive, constipation, and developmental delay | CD | Intestinal biopsy | DGP IgG and TTG IgA | 1 | NA | 1/1 | 0 | NA | NA |
Pacitto 2017 [27] | Case report, Italy | 1 | 0 | 23 mo | 1 child presenting with malabsorption syndrome and peripheral neuropathy | CD | Intestinal biopsy | DGP IgG and TTG IgA | 1 | NA | 1/1 | 1/1 | NA | NA |
Liu 2015 [28] | Longitudinal cohort, USA | 1243 | NR | 0.5–17 yr | 1243 newborn at genetic risk of CD screened with both index tests | CD | Intestinal biopsy | DGP IgG and TTG IgA | 50 | 1193 | 50/50 | 50/50 | NR | NR |
Lammi 2016 [29] | Longitudinal cohort, Finland | 291 | NR | 6–48 mo | 291 newborn at genetic risk of CD screened with both index tests | CD | Intestinal biopsy | DGP IgG and TTG IgA | 9 | 282 | 9/9 | 9/9 | NR | NR |
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Catassi, G.N.; Pulvirenti, A.; Monachesi, C.; Catassi, C.; Lionetti, E. Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis. Nutrients 2022, 14, 7. https://doi.org/10.3390/nu14010007
Catassi GN, Pulvirenti A, Monachesi C, Catassi C, Lionetti E. Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis. Nutrients. 2022; 14(1):7. https://doi.org/10.3390/nu14010007
Chicago/Turabian StyleCatassi, Giulia N., Alfredo Pulvirenti, Chiara Monachesi, Carlo Catassi, and Elena Lionetti. 2022. "Diagnostic Accuracy of IgA Anti-Transglutaminase and IgG Anti-Deamidated Gliadin for Diagnosis of Celiac Disease in Children under Two Years of Age: A Systematic Review and Meta-Analysis" Nutrients 14, no. 1: 7. https://doi.org/10.3390/nu14010007