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Volume 14
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10.3390/nu14102128
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Article

Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production

by
Mylene Anwar
1,2,
Sonya Mros
3,
Michelle McConnell
3 and
Alaa El-Din A. Bekhit
1,*
1
Department of Food Science, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand
2
Department of Food Science, Central Mindanao University, University Town, Musuan, Maramag 8710, Bukidnon, Philippines
3
Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(10), 2128; https://doi.org/10.3390/nu14102128
Submission received: 28 February 2022 / Revised: 12 May 2022 / Accepted: 12 May 2022 / Published: 19 May 2022
(This article belongs to the Topic Probiotics, Prebiotics and Postbiotics in Human Health)
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Abstract

In the past decades, the regulation of pro-inflammatory cytokine production, including interleukin-8 (IL-8), has been the goal of many targeted therapeutic interventions for Necrotising enterocolitis (NEC), a gastrointestinal disease commonly associated with a very low birth weight in preterm infants. In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated. The TNF-α stimulated HT-29 cells were incubated with undigested or digested Tc-WS-NSPs (CE or ICE), probiotics, and their synbiotic mixtures with Klebsiella oxytoca, an NEC-positive-associated pathogen. Overall, the synbiotic mixtures of digested Tc-WS-NSP-ICE and high bacterial concentrations of L. acidophilus (5.57 × 109), B. breve (2.7 × 108 CFU/mL), and B. infantis (1.53 × 108) demonstrated higher (42.0%, 45.0%, 43.1%, respectively) ability to downregulate IL-8 compared to the sole use of Tc-WS-NSPs (24.5%), or the probiotics L. acidophilus (32.3%), B. breve (37.8%), or B. infantis (33.1%). The ability demonstrated by the Tc-WS-NSPs, the probiotics, and their synbiotics mixtures to downregulate IL-8 production in the presence of an NEC-positive-associated pathogen may be useful in the development of novel prophylactic agents against NEC.
Keywords: taro (Colocasia esculenta); water-soluble non-starch polysaccharide; probiotics; synbiotic; interleukin 8; necrotising enterocolitis taro (Colocasia esculenta); water-soluble non-starch polysaccharide; probiotics; synbiotic; interleukin 8; necrotising enterocolitis

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MDPI and ACS Style

Anwar, M.; Mros, S.; McConnell, M.; Bekhit, A.E.-D.A. Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production. Nutrients 2022, 14, 2128. https://doi.org/10.3390/nu14102128

AMA Style

Anwar M, Mros S, McConnell M, Bekhit AE-DA. Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production. Nutrients. 2022; 14(10):2128. https://doi.org/10.3390/nu14102128

Chicago/Turabian Style

Anwar, Mylene, Sonya Mros, Michelle McConnell, and Alaa El-Din A. Bekhit. 2022. "Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production" Nutrients 14, no. 10: 2128. https://doi.org/10.3390/nu14102128

APA Style

Anwar, M., Mros, S., McConnell, M., & Bekhit, A. E.-D. A. (2022). Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production. Nutrients, 14(10), 2128. https://doi.org/10.3390/nu14102128

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