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Nutrients
Volume 14
Issue 11
10.3390/nu14112327
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Article

Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study

by
Frances A. Tylavsky
1,
Luhang Han
1,
Lauren M. Sims Taylor
1,
W. Alex Mason
1,
Kecia N. Carroll
2,
Nicole R. Bush
3,4,
Kaja Z. LeWinn
3,
Melissa M. Melough
5,
Terryl J. Hartman
6 and
Qi Zhao
1,*
1
Department of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
2
Division of General Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3
Department of Psychiatry and Behavioral Health, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94118, USA
4
Department of Pediatrics, University of California San Francisco, San Francisco, CA 94118, USA
5
Center for Child Health, Behavior and Development, Seattle Children’s Research Institute, Seattle, WA 98121, USA
6
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 303221, USA
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(11), 2327; https://doi.org/10.3390/nu14112327
Submission received: 29 April 2022 / Revised: 26 May 2022 / Accepted: 30 May 2022 / Published: 1 June 2022
(This article belongs to the Section Nutrition in Women)
Versions Notes

Abstract

The objective of this study was to calculate an oxidative balance score (OBS) utilizing diet and lifestyle information collected from 1322 women during the second trimester of pregnancy in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. An energy-adjusted OBS was calculated using nutrient information from a Food Frequency Questionnaire (FFQ), lifestyle measures, and plasma folate and vitamin D levels. Using the least absolute shrinkage and selection operator method, 91 food items from the FFQ were selected and they accounted for 82% of the variance in the OBS, with cruciferous vegetables, citrus fruits, fruit juice, and coffee being among the highest anti-oxidant predictors, and red meats and alcohol among the highest pro-oxidant contributors. Urinary F2-isoprostane, an objective indicator of oxidative stress, was lower with increasing OBS quintiles in a stairstep manner (p for trend = 0.0003), suggesting the possible utility of the OBS as an indicator of oxidative stress. The OBS was moderately correlated with the Healthy Eating Index (correlation coefficient = 0.6076), suggesting it provides a distinct measure of a healthy diet. In conclusion, the OBS may serve as a valid reflective indicator of urinary F2-isoprostanes and an epidemiological tool to inform intervention studies, in order to minimize oxidative stress during pregnancy.
Keywords: anti-oxidant balance; dietary intake; isoprostanes; lifestyle; oxidative stress; pregnancy anti-oxidant balance; dietary intake; isoprostanes; lifestyle; oxidative stress; pregnancy

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MDPI and ACS Style

Tylavsky, F.A.; Han, L.; Sims Taylor, L.M.; Mason, W.A.; Carroll, K.N.; Bush, N.R.; LeWinn, K.Z.; Melough, M.M.; Hartman, T.J.; Zhao, Q. Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study. Nutrients 2022, 14, 2327. https://doi.org/10.3390/nu14112327

AMA Style

Tylavsky FA, Han L, Sims Taylor LM, Mason WA, Carroll KN, Bush NR, LeWinn KZ, Melough MM, Hartman TJ, Zhao Q. Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study. Nutrients. 2022; 14(11):2327. https://doi.org/10.3390/nu14112327

Chicago/Turabian Style

Tylavsky, Frances A., Luhang Han, Lauren M. Sims Taylor, W. Alex Mason, Kecia N. Carroll, Nicole R. Bush, Kaja Z. LeWinn, Melissa M. Melough, Terryl J. Hartman, and Qi Zhao. 2022. "Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study" Nutrients 14, no. 11: 2327. https://doi.org/10.3390/nu14112327

APA Style

Tylavsky, F. A., Han, L., Sims Taylor, L. M., Mason, W. A., Carroll, K. N., Bush, N. R., LeWinn, K. Z., Melough, M. M., Hartman, T. J., & Zhao, Q. (2022). Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study. Nutrients, 14(11), 2327. https://doi.org/10.3390/nu14112327

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