Postoperative Diet with an Oligomeric Hyperproteic Normocaloric Supplement versus a Supplement with Immunonutrients in Colorectal Cancer Surgery: Results of a Multicenter, Double-Blind, Randomized Clinical Trial
, Pedro Vicente Fernández-Fernández 1, Elena Ruiz-Úcar 2, Amparo Solana-Bueno 3, Pedro Antonio Parra-Baños 1, Beatriz MartÃnez-Torres 2, Roberto Lozoya-Trujillo 3, MarÃa Dolores Ruiz-Carmona 3, Marina Alarcón-Iranzo 3, Lorena Rentero-Redondo 4, Emilio Peña-Ros 1, José Manuel Muñoz-Camarena 1, Milagros Carrasco-Prats 1, MarÃa RamÃrez-Faraco 1, Paloma Portillo-Ortega 5 and Antonio AlbarracÃn-MarÃn-Blázquez 1
Round 1
Reviewer 1 Report
The manuscript is well written and the comparation between OHN and IN post-operative supplementation is dealth with well. The results were clearly argomented. I support the authors to continue the study to better understand and improve the post-operative nutritional management of patients with colorectal cancer. I don't have suggestions for the authors.
Reviewer 2 Report
The clinical study (noninferiority trial) evaluated and compared the effects, including tolerance, of two supplements during rehabilitation after colorectal cancer resection (an oligomeric hyperproteic normocaloric supplement (OHN; experimental arm) and an immunonutritional (IN; active comparator) supplement).
The study was designed in accordance with applicable ethics regulations and current clinical trial design trends and guidelines.
The manuscript is well written and in a coherent manner. The stated conclusions are supported by results.
