Next Article in Journal
Nutritional Niches of Cancer Therapy-Induced Senescent Cells
Previous Article in Journal
Prognostic Nutritional Index as a Predictor of Diabetic Nephropathy Progression
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 14
Issue 17
10.3390/nu14173635
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Reconfiguration of Gut Microbiota and Reprogramming of Liver Metabolism with Phycobiliproteins Bioactive Peptides to Rehabilitate Obese Rats

by
Jing Liu
1,2,
Dongyu Zhen
2,
Changbao Hu
2,
Yawen Liu
1,2,
Xuanri Shen
2,3,
Pengcheng Fu
1,4,* and
Yanfu He
2,3,*
1
State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou 570228, China
2
School of Food Science and Engineering, Hainan University, Haikou 570228, China
3
Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Hainan University, Haikou 570228, China
4
Weihai UIC Biotechnology, Inc., 23 Shenzhen Road, Gaocun, Wendeng District, Weihai 264408, China
*
Authors to whom correspondence should be addressed.
Nutrients 2022, 14(17), 3635; https://doi.org/10.3390/nu14173635
Submission received: 21 July 2022 / Revised: 10 August 2022 / Accepted: 31 August 2022 / Published: 2 September 2022
(This article belongs to the Topic Applied Sciences in Functional Foods - 2nd Volume)
Browse Figures
Review Reports Versions Notes

Abstract

Phycobiliproteins (derived from Arthrospira platensis) bioactive peptide extracts (PPE) possess multiple pharmacological effects in the mitigation of human metabolic disorders. The role of PPE in the treatment of diet-induced obesity and the understanding of the underlying mechanism between the gut microbiome and metabolic blood circulation for obese patients remains poorly understood. In this study, we showed that PPE attenuated obesity by reducing body weight, and ameliorated glucose and lipid indexes in serum. In particular, PPE is postulated to mitigate liver steatosis and insulin resistance. On the other hand, dietary treatment with PPE was found to “reconfigure” the gut microbiota in the way that the abundances were elevated for Akkermansia_muciniphila, beneficial Lactobacillus and Romboutsia, SCFA-producing species Faecalibacterium prausnitzii, Lachnospiraceae_bacterium, Clostridiales_bacterium, probiotics Clostridium sp., Enterococcus faecium, and Lactobacillus_johnsonii, while the abundance of Firmicutes was reduced and that of Bacteroidetes was increased to reverse the imbalance of Firmicutes/Bacteroidetes ratio. Finally, the metabolomics of circulating serum using UHPLC-MS/MS illustrated that PPE supplementation indeed promoted lipid metabolism in obese rats. As summary, it was seen that PPE reprogrammed the cell metabolism to prevent the aggravation of obesity. Our findings strongly support that PPE can be regarded as a potential therapeutic dietary supplement for obesity.
Keywords: phycobiliproteins; bioactive peptides extract; obesity; gut microbiome; serum metabolome phycobiliproteins; bioactive peptides extract; obesity; gut microbiome; serum metabolome

Share and Cite

MDPI and ACS Style

Liu, J.; Zhen, D.; Hu, C.; Liu, Y.; Shen, X.; Fu, P.; He, Y. Reconfiguration of Gut Microbiota and Reprogramming of Liver Metabolism with Phycobiliproteins Bioactive Peptides to Rehabilitate Obese Rats. Nutrients 2022, 14, 3635. https://doi.org/10.3390/nu14173635

AMA Style

Liu J, Zhen D, Hu C, Liu Y, Shen X, Fu P, He Y. Reconfiguration of Gut Microbiota and Reprogramming of Liver Metabolism with Phycobiliproteins Bioactive Peptides to Rehabilitate Obese Rats. Nutrients. 2022; 14(17):3635. https://doi.org/10.3390/nu14173635

Chicago/Turabian Style

Liu, Jing, Dongyu Zhen, Changbao Hu, Yawen Liu, Xuanri Shen, Pengcheng Fu, and Yanfu He. 2022. "Reconfiguration of Gut Microbiota and Reprogramming of Liver Metabolism with Phycobiliproteins Bioactive Peptides to Rehabilitate Obese Rats" Nutrients 14, no. 17: 3635. https://doi.org/10.3390/nu14173635

APA Style

Liu, J., Zhen, D., Hu, C., Liu, Y., Shen, X., Fu, P., & He, Y. (2022). Reconfiguration of Gut Microbiota and Reprogramming of Liver Metabolism with Phycobiliproteins Bioactive Peptides to Rehabilitate Obese Rats. Nutrients, 14(17), 3635. https://doi.org/10.3390/nu14173635

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop