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Nutrients
Volume 14
Issue 17
10.3390/nu14173646
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Article

Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation

by
Ayoub Mitha
1,2,
Sofia Söderquist Kruth
3,4,
Sara Bjurman
5,
Alexander Rakow
4,6 and
Stefan Johansson
1,5,*
1
Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, 17177 Stockholm, Sweden
2
CHU Lille, Paediatric and Neonatal Intensive Care Transport Unit, Department of Emergency Medicine, SAMU 59, Lille University Hospital, F-59000 Lille, France
3
Women’s Health and Allied Health Professional Theme, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden
4
Department of Women’s and Children’s Health, Karolinska Institutet, 17177 Stockholm, Sweden
5
Sachs Children and Youth Hospital, Södersjukhuset, 11883 Stockholm, Sweden
6
Department of Neonatology, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(17), 3646; https://doi.org/10.3390/nu14173646
Submission received: 4 July 2022 / Revised: 30 August 2022 / Accepted: 31 August 2022 / Published: 3 September 2022
(This article belongs to the Special Issue The Role of Feeding Practice and Early Nutrition in Infant Growth, Metabolism and Body Composition)
Review Reports Versions Notes

Abstract

While probiotics are reported to reduce the risks of neonatal morbidities, less is known about probiotics and feeding tolerance. With this retrospective cohort study, we investigate whether introduction of probiotic supplementation as the standard of care was associated with fewer neonatal morbidities and improved feeding tolerance in very preterm infants. Using the Swedish Neonatal Quality Register, 345 live-born very preterm infants (28–31 weeks’ gestation), from January 2019–August 2021, in NICUs in Stockholm, Sweden, either received probiotic supplementation (Bifidobacterium infantis, Bifidobacterium lactis, Streptococcusthermophilus) (139) or no supplementation (206); they were compared regarding a primary composite outcome of death, sepsis, and/or necrotising enterocolitis and secondary outcomes: time to full enteral feeding and antibiotics use. Probiotics seemed associated with a reduced risk of the composite outcome (4.3% versus 9.2%, p = 0.08). In the subgroup of 320 infants without the primary outcome, probiotics were associated with shorter time to full enteral feeding (6.6 days versus 7.2 days) and less use of antibiotics (5.2 days versus 6.1 days). Our findings suggest that probiotics improve feeding tolerance and further support that very preterm infants may benefit from probiotic supplementation.
Keywords: probiotic supplementation; very preterm infants; feeding tolerance; neonatal morbidities; necrotising enterocolitis; full enteral feeding; antibiotic probiotic supplementation; very preterm infants; feeding tolerance; neonatal morbidities; necrotising enterocolitis; full enteral feeding; antibiotic

Share and Cite

MDPI and ACS Style

Mitha, A.; Kruth, S.S.; Bjurman, S.; Rakow, A.; Johansson, S. Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation. Nutrients 2022, 14, 3646. https://doi.org/10.3390/nu14173646

AMA Style

Mitha A, Kruth SS, Bjurman S, Rakow A, Johansson S. Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation. Nutrients. 2022; 14(17):3646. https://doi.org/10.3390/nu14173646

Chicago/Turabian Style

Mitha, Ayoub, Sofia Söderquist Kruth, Sara Bjurman, Alexander Rakow, and Stefan Johansson. 2022. "Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation" Nutrients 14, no. 17: 3646. https://doi.org/10.3390/nu14173646

APA Style

Mitha, A., Kruth, S. S., Bjurman, S., Rakow, A., & Johansson, S. (2022). Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation. Nutrients, 14(17), 3646. https://doi.org/10.3390/nu14173646

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