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Nutrients
Volume 14
Issue 19
10.3390/nu14193930
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Review
Peer-Review Record

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus

Nutrients 2022, 14(19), 3930; https://doi.org/10.3390/nu14193930
by Jessica M. Williamson *, Anya L. Arthurs, Melanie D. Smith, Claire T. Roberts *,† and Tanja Jankovic-Karasoulos *,†
Reviewer 1:
Roberto Miniero
Reviewer 2:
Hunter W. Korsmo
Nutrients 2022, 14(19), 3930; https://doi.org/10.3390/nu14193930
Submission received: 31 August 2022 / Revised: 12 September 2022 / Accepted: 20 September 2022 / Published: 22 September 2022
(This article belongs to the Special Issue Maternal Nutrition in Pregnancy)

Round 1

Reviewer 1 Report

The Authors deal with a very interesting topic  The literature has been carefully studied  and well discussed

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Williamson et al. provided a detailed and comprehensive review on the one carbon nutrients in GDM. The authors provided an extensive list for some potential mechanisms from studies that investigated one carbon disturbances, indicating the influence in health outcomes. The authors also  describe the methyl folate trap in GDM with great detail (PMID: 34210607).

The article lacks an indication of metabolic subcellular localization. One carbon metabolism, especially the production of betaine from choline, rely on effective mitochondria (PMID: 23906661). GDM compromises ova mitochondria (PMID: 32945868). Including these details will include important context to otherwise trivial disturbances in one carbon nutrients.

The article also lacks a clear indication of one-carbon metabolites and their direct influence on the disturbed mechanism of action of insulin in the insulinopathy. Detailing or proposing a mechanism of direct action of one carbon nutrients to the impaired insulin pathway could be included to improve clarity and relevance. (PMIDs: 33498674, 34754676, and 33091596)

Overall, the paper is informative and includes a good review of the current literature. Possibly try to re-render the figures as they seemed a bit pixelated.

Author Response

Please see the attachment

Author Response File: Author Response.docx

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