Body Composition in Multiple Sclerosis Patients and Its Relationship to the Disability Level, Disease Duration and Glucocorticoid Therapy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Studied Population
2.2. Anthropometric Measurements and Body Composition Analysis
2.3. Ethical Considerations
2.4. Statistical Analysis
3. Results
3.1. Anthropometrical Measures and Body Composition Variables by Disability Status
3.2. Correlation between Disability Status, MS Duration Time and Anthropometrical Measures/Body Composition Variables
3.3. Anthropometrical Measures, Body Composition Variables and MS Duration Time by Glucocorticoid Therapy
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Studied Population n = 176 (F/M 128/48) | ||||
---|---|---|---|---|
Mean | Minimum | Maximum | SD | |
Age (years) [F/M] | 45.68 [45.67/45.71] | 20.00 | 73.00 | 12.01 |
MS duration (years) [F/M] | 10.92 [10.60/11.80] | 0.17 | 37.00 | 7.91 |
EDSS initial [F/M] | 2.2 [2.2/2.2] | 1.0 | 4.5 | 0.7 |
EDSS [F/M] | 3.3 [3.3/3.3] | 1.0 | 6.5 | 1.6 |
Height (cm) [F/M] | 167.2 [163.8/176.3] ** | 152.1 | 196.1 | 8.7 |
Weight (kg) [F/M] | 69.5 [65.3/80.8] ** | 40.6 | 114. | 16.0 |
BMI (kg/m2) [F/M] | 24.87 [24.4/25.9] | 16.10 | 40.30 | 4.94 |
Waist c. (cm) [F/M] | 90.4 [87.9/97.1] ** | 61.0 | 126.0 | 13.5 |
Hip c. (cm) [F/M] | 100.9 [100.6/101.9] | 73.5 | 129.0 | 9.3 |
WHtR [F/M] | 0.54 [0.54/0.55] | 0.38 | 0.75 | 0.08 |
WHR [F/M] | 0.89 [0.87/0.96] ** | 0.66 | 1.22 | 0.08 |
FM (kg) [F/M] | 20.7 [21.1/19.6] | 2.6 | 52.7 | 9.2 |
FMI (kg/m2) [F/M] | 7.43 [7.83/6.36] * | 1.02 | 18.90 | 3.33 |
FM (%) [F/M] | 28.8 [30.8/23.6] ** | 6.2 | 48.1 | 8.4 |
FFM (kg) [F/M] | 48.9 [44.3/61.1] ** | 34.8 | 75.6 | 10.1 |
FFMI (kg/m2) [F/M] | 17.35 [16.1/19.6] ** | 13.21 | 23.28 | 2.33 |
FFM (%) [F/M] | 71.2 [69.2/76.3] ** | 51.9 | 93.8 | 8.3 |
Overall (n = 176) | Mild (n = 135) | Moderate (n = 41) | p-Value Student’s t-Test | |
---|---|---|---|---|
Age (years) | 45.68 (12.01) | 42.88 (11.19) | 54.90 (9.09) | <0.0000001 |
MS duration (years) | 10.92 (7.91) | 9.29 | 16.30 | <0.0000001 |
Initial EDSS | 2.2 (0.7) | 2.0 (0.7) | 2.7 (0.6) | <0.000001 |
Present EDSS | 3.3 (1.6) | 2.5 (0.9) | 5.8 (0.6) | <0.0000001 |
ΔEDSS | 1.1 (1.5) | 0.5 (0.9) | 3.2 (0.9) | <0.0000001 |
Height (cm) | 167.2 (8.7) | 167.3 (8.5) | 165.8 (9.0) | NS |
Weight (kg) | 69.5 (16.0) | 69.2 (16.9) | 70.3 (12.9) | NS |
BMI (kg/m2) | 24.87 (4.94) | 24.60 (5.00) | 25.73 (4.70) | NS |
Waist c. (cm) | 90.4 (13.5) | 88.7 (13.4) | 95.9 (12.4) | <0.01 |
Hip c. (cm) | 100.9 (9.3) | 100.5 (8.6) | 102.5 (9.4) | NS |
WHtR | 0.54 (0.08) | 0.53 (0.07) | 0.58 (0.08) | <0.001 |
WHR | 0.89 (0.08) | 0.88 (0.08) | 0.94 (0.10) | <0.001 |
FM (kg) | 20.7 (9.2) | 7.2 (3.3) | 8.3 (3.2) | NS |
FM (%) | 28.8 (8.4) | 28.1 (8.5) | 31.4 (7.4) | <0.05 |
FMI (kg/m2) | 7.43 (3.33) | 7.16 (3.34) | 8.29 (3.20) | NS |
FFM (kg) | 48.9 (10.1) | 49.10 (10.37) | 48.07 (8.96) | NS |
FFM (%) | 71.2 (8.3) | 71.9 (8.4) | 68.6 (7.6) | <0.05 |
FFMI (kg/m2) | 17.35 (2.33) | 17.33 (2.34) | 17.41 (2.29) | NS |
Overall (n = 176) | RRMS (n = 123) | SPMS (n = 53) | p-Value Student’s t-Test | |
---|---|---|---|---|
Age (years) | 45.68 (12.01) | 40.87 (9.69) | 56.85 (9.13) | <0.0000001 |
MS duration (years) | 10.92 (7.91) | 8.31 (5.69) | 16.99 (8.99) | <0.0000001 |
Present EDSS | 3.3 (1.6) | 2.6 (1.2) | 5.0 (1.4) | <0.0000001 |
BMI (kg/m2) | 24.87 (4.94) | 24.36 (5.05) | 26.04 (4.52) | <0.05 |
Waist c. (cm) | 90.4 (13.5) | 87.9 (13.6) | 96.1 (11.5) | <0.001 |
Hip c. (cm) | 100.9 (9.3) | 100.3 (9.6) | 102.7 (8.5) | NS |
WHtR | 0.54 (0.08) | 0.52 (0.07) | 0.58 (0.07) | <0.00001 |
WHR | 0.89 (0.08) | 0.87 (0.07) | 0.93 (0.08) | <0.00001 |
FM (kg) | 20.7 (9.2) | 19.21 (9.4) | 22.9 (8.3) | <0.05 |
FM (%) | 28.8 (8.4) | 27.6 (8.2) | 31.7 (8.0) | <0.01 |
FMI (kg/m2) | 7.43 (3.33) | 6.96 (3.23) | 8.50 (3.34) | <0.01 |
FFM (kg) | 48.9 (10.1) | 49.14 (10.62) | 48.19 (8.59) | NS |
FFM (%) | 71.2 (8.3) | 72.4 (8.1) | 68.2 (8.2) | <0.01 |
FFMI (kg/m2) | 17.35 (2.33) | 17.27 (2.46) | 17.51 (1.97) | NS |
Females (n = 128) | Mild (n = 99) | Moderate (n = 29) | p-Value |
BMI (kg/m2) | 24.13 (5.23) | 25.49 (4.96) | NS |
Waist c. (cm) | 86.2 (13.3) | 93.8 (12.8) | <0.01 |
Hip c. (cm) | 99.9 (10.3) | 103.0 (8.7) | NS |
WHtR | 0.52 (0.08) | 0.58 (0.08) | <0.01 |
WHR | 0.88 (0.07) | 0.91 (0.09) | <0.01 |
FM (kg) | 20.5 (10.2) | 23.1 (7.7) | NS |
FM (%) | 29.9 (8.6) | 33.8 (5.5) | <0.05 |
FMI (kg/m2) | 7.53 (3.57) | 8.84 (3.12) | NS |
FFM (kg) | 44.5 (6.2) | 43.7 (4.6) | NS |
FFM (%) | 70.1 (8.5) | 66.0 (5.6) | <0.05 |
FFMI (kg/m2) | 16.46 (1.80) | 16.65 (2.10) | NS |
Males (n = 48) | Mild (n = 36) | Moderate (n = 12) | p-Value |
BMI (kg/m2) | 25.88 (4.11) | 26.33 (4.15) | NS |
Waist c. (cm) | 95.8 (11.1) | 100.9 (10.3) | NS |
Hip c. (cm) | 102.1 (7.1) | 101.3 (7.9) | NS |
WHtR | 0.54 (0.06) | 0.58 (0.08) | NS |
WHR | 0.94 (0.06) | 1.00 (0.09) | <0.05 |
FM (kg) | 19.28 (7.56) | 20.70 (7.92) | NS |
FM (%) | 23.0 (5.9) | 25.4 (8.2) | NS |
FMI (kg/m2) | 6.15 (2.37) | 6.98 (3.12) | NS |
FFM (kg) | 61.86 (8.74) | 58.72 (7.93) | NS |
FFM (%) | 71.9 (8.4) | 68.6 (7.6) | NS |
FFMI (kg/m2) | 19.71 (2.00) | 19.26 (1.61) | NS |
BMI | Waist c. | WHtR | WHR | FM (%) | FFM (%) | |
---|---|---|---|---|---|---|
Initial EDSS | −0.018 | 0.018 | 0.038 | 0.097 | 0.009 | −0.018 |
EDSS | 0.099 | 0.234 ** | 0.293 **** | 0.287 *** | 0.191 * | −0.206 ** |
ΔEDSS | 0.115 | 0.250 ** | 0.308 **** | 0.275 *** | 0.201 ** | −0.213 ** |
MS time | 0.146 | 0.180 * | 0.229 ** | 0.254 ** | 0.183 * | −0.188 * |
Y | x | |||||
---|---|---|---|---|---|---|
Variable | b Coefficient | Significance | Variable | b Coefficient | Significance | |
EDSS | Waist c. | 0.155 | p < 0.01 | MS time | 0.442 | p < 0.0000001 |
WHtR | 0.195 | p < 0.01 | 0.426 | |||
WHR | 0.180 | p < 0.01 | 0.422 | |||
FM% | 0.109 | p = 0.109 | 0.450 | |||
FFM% | −0.122 | p = 0.074 | 0.447 | |||
ΔEDSS | Waist c. | 0.176 | p < 0.01 | MS time | 0.432 | p < 0.0000001 |
WHtR | 0.215 | p < 0.01 | 0.415 | |||
WHR | 0.168 | p < 0.05 | 0.419 | |||
FM% | 0.127 | p = 0.062 | 0.440 | |||
FFM% | −0.137 | p < 0.05 | 0.438 |
Glucocorticoid Therapy | |||
---|---|---|---|
No (n = 117) | Yes (n = 59) | p-Value (t-Student Test) | |
MS time (years) | 9.92 (7.07) | 12.91 (9.09) | <0.05 |
Initial EDSS | 2.16 (0.74) | 2.19 (0.74) | NS |
EDSS | 3.07 (1.63) | 3.66 (1.62) | <0.05 |
ΔEDSS | 0.91 (1.45) | 1.47 (1.41) | <0.05 |
BMI (kg/m2) | 24.36 (4.67) | 25.87 (5.36) | NS |
Waist c. (cm) | 89.1 (13.19) | 93.0 (13.76) | NS |
Hip c. (cm) | 100.0 (9.1) | 102.8 (9.6) | NS |
WHtR | 0.53 (0.08) | 0.56 (0.08) | <0.05 |
WHR | 0.89 (0.09) | 0.90 (0.08) | NS |
FM (kg) | 19.52 (8.43) | 22.98 (10.24) | <0.05 |
FM (%) | 27.71 (8.04) | 31.09 (8.59) | <0.05 |
FMI (kg/m2) | 6.98 (3.04) | 8.31 (3.73) | <0.05 |
FFM (kg) | 49.06 (10.43) | 48.46 (9.31) | NS |
FFM (%) | 72.31 (7.96) | 68.86 (8.65) | <0.01 |
FFMI (kg/m2) | 17.36 (2.43) | 17.32 (2.12) | NS |
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Matusik, E.; Durmala, J.; Ksciuk, B.; Matusik, P. Body Composition in Multiple Sclerosis Patients and Its Relationship to the Disability Level, Disease Duration and Glucocorticoid Therapy. Nutrients 2022, 14, 4249. https://doi.org/10.3390/nu14204249
Matusik E, Durmala J, Ksciuk B, Matusik P. Body Composition in Multiple Sclerosis Patients and Its Relationship to the Disability Level, Disease Duration and Glucocorticoid Therapy. Nutrients. 2022; 14(20):4249. https://doi.org/10.3390/nu14204249
Chicago/Turabian StyleMatusik, Edyta, Jacek Durmala, Barbara Ksciuk, and Pawel Matusik. 2022. "Body Composition in Multiple Sclerosis Patients and Its Relationship to the Disability Level, Disease Duration and Glucocorticoid Therapy" Nutrients 14, no. 20: 4249. https://doi.org/10.3390/nu14204249
APA StyleMatusik, E., Durmala, J., Ksciuk, B., & Matusik, P. (2022). Body Composition in Multiple Sclerosis Patients and Its Relationship to the Disability Level, Disease Duration and Glucocorticoid Therapy. Nutrients, 14(20), 4249. https://doi.org/10.3390/nu14204249