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Peer-Review Record

Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson’s Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis

Nutrients 2022, 14(21), 4632; https://doi.org/10.3390/nu14214632
by Kasthuri Bai Magalingam 1,2, Premdass Ramdas 3, Sushela Devi Somanath 4, Kanga Rani Selvaduray 5, Saatheeyavaane Bhuvanendran 1 and Ammu Kutty Radhakrishnan 1,6,*
Reviewer 1:
Reviewer 2: Anonymous
Nutrients 2022, 14(21), 4632; https://doi.org/10.3390/nu14214632
Submission received: 19 August 2022 / Revised: 27 October 2022 / Accepted: 1 November 2022 / Published: 3 November 2022
(This article belongs to the Section Nutrition and Public Health)

Round 1

Reviewer 1 Report

See my comments in the attached PDF file.

Comments for author File: Comments.pdf

Author Response

Please see file attached

Author Response File: Author Response.pdf

Reviewer 2 Report

1) Getting to the conclusion that TRF exerts profound neuroprotective effects by regulating pathways that hamper the development of PD is too broad to make. To make that conclusion, there is a need to add more data with human patient-derived iPSC-derived neurons, patients' tissues, in vivo models, etc. to make that conclusion. 

2) Figures are hard-to-read. Need to improve the resolution of the text.

2) Fig 5 has too much information and is difficult for readers to understand. 

Author Response

Please see file attached

Author Response File: Author Response.pdf

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