Effect of Alpha-S1-Casein Tryptic Hydrolysate and L-Theanine on Poor Sleep Quality: A Double Blind, Randomized Placebo-Controlled Crossover Trial

Round 1

Reviewer 1 Report

This manuscript was well-prepared. The introduction supports the study design and the conclusions tell a concise story. I wish that more graphs depicting the data had been included instead of tables however.

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

Dear Authors:

I reviewed the manuscript entitled “Effect of Alpha-S1-Casein Tryptic Hydrolysate and L-Theanine on Poor Sleep Quality: A Double Blind, Randomized Placebo-Controlled Crossover Trial”.  It is an interesting manuscript with a good concept and a better approach to insomnia than using synthetic medications.  However, the basic material that was derived and used (Alpha-S1-Casein Tryptic Hydrolysate) comes from a natural food, which is milk.  As a Food Scientist, I know that it will not have an adverse effect on human body.  The following minor corrections are recommended. 

1. The sentences 35-38 are not clear and may want to split it into two sentences.  
2. The sentence 50 “These medications are also might be inappropriate….please change it to “These medications may also be inappropriate ….”.
3. In sentences 64-65, the dose used for rats was 300 mg/kg/day that translates into 21 grams for an average man, which is a large dose. It may still be OK for humans?   
4. The sentences 94-96, can be changed to “…at the same time other data were collected in a quiet setting”.

     5.  In the sentence 157, you may want to add “…and samples with very                low levels of salivary cortisol, an indicator of chronic insomnia [27]. 

Author Response

Please see the attachment 

Author Response File: Author Response.docx