Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank

Mazzucca, Camilla Barbero; Scotti, Lorenza; Cappellano, Giuseppe; Barone-Adesi, Francesco; Chiocchetti, Annalisa

doi:10.3390/nu14081554

Open AccessArticle

Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank

by

Camilla Barbero Mazzucca

^1,2,

Lorenza Scotti

³,

Giuseppe Cappellano

^1,2

,

Francesco Barone-Adesi

^3,†

and

Annalisa Chiocchetti

^1,2,*,†

¹

Dipartimento di Scienze Della Salute, Interdisciplinary Research Center of Autoimmune Diseases—IRCAD, Università del Piemonte Orientale, 28100 Novara, Italy

²

Center for Translational Research on Autoimmune and Allergic Diseases—CAAD, Università del Piemonte Orientale, 28100 Novara, Italy

³

Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, 28100 Novara, Italy

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Nutrients 2022, 14(8), 1554; https://doi.org/10.3390/nu14081554

Submission received: 10 February 2022 / Revised: 31 March 2022 / Accepted: 5 April 2022 / Published: 8 April 2022

(This article belongs to the Special Issue Diet, Environmental Factors and Autoimmune Diseases: Can We Find a Path for Preventive Lifestyle?)

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints. The multifactorial etiopathogenesis of RA has been heavily investigated, but is still only partially understood. Diet can represent both a risk factor and a protective factor, based on some evidence that suggests specific properties of certain foods and their ability to increase/reduce inflammation. To date, the studies done on this topic provide discordant results and are heterogeneous in terms of design and cohort size. In this work, we investigated for the first time the relationship between nutrition and the risk of RA onset using a sample size of about half a million subjects from one of the largest publicly available biobanks that is the UK biobank. Results showed that oily fish, alcohol, coffee and breakfast cereals have protective roles in RA; whereas, tea can increase the risk of RA. In conclusion, the obtained results confirm that diet plays key roles in RA, either by promoting or by preventing RA onset and development. Future research should focus on unravelling the effects of dietary habits on immune-mediated diseases to establish better preventive strategies.

Keywords: dietary habits; autoimmunity; rheumatoid arthritis; UK biobank

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MDPI and ACS Style

Mazzucca, C.B.; Scotti, L.; Cappellano, G.; Barone-Adesi, F.; Chiocchetti, A. Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank. Nutrients 2022, 14, 1554. https://doi.org/10.3390/nu14081554

AMA Style

Mazzucca CB, Scotti L, Cappellano G, Barone-Adesi F, Chiocchetti A. Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank. Nutrients. 2022; 14(8):1554. https://doi.org/10.3390/nu14081554

Chicago/Turabian Style

Mazzucca, Camilla Barbero, Lorenza Scotti, Giuseppe Cappellano, Francesco Barone-Adesi, and Annalisa Chiocchetti. 2022. "Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank" Nutrients 14, no. 8: 1554. https://doi.org/10.3390/nu14081554

APA Style

Mazzucca, C. B., Scotti, L., Cappellano, G., Barone-Adesi, F., & Chiocchetti, A. (2022). Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank. Nutrients, 14(8), 1554. https://doi.org/10.3390/nu14081554

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank

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