Next Article in Journal
The Involvement of Intestinal Tryptophan Metabolism in Inflammatory Bowel Disease Identified by a Meta-Analysis of the Transcriptome and a Systematic Review of the Metabolome
Previous Article in Journal
Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Previous Article in Special Issue
Colorectal Cancer and the Role of the Gut Microbiota—Do Medical Students Know More Than Other Young People?—Cross-Sectional Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 15
Issue 13
10.3390/nu15132885
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations

by
Alice Zaramella
1,2,*,
Diletta Arcidiacono
2,
Daniele Nucci
3,
Federico Fabris
4,
Clara Benna
1,
Salvatore Pucciarelli
1,
Matteo Fassan
5,6,
Alberto Fantin
2,
Vallì De Re
7,
Renato Cannizzaro
8,9 and
Stefano Realdon
8
1
Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy
2
Gastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy
3
Dietetics and Clinical Nutrition Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy
4
Department of Biomedical Sciences, University of Padua, Viale Colombo 3, 35121 Padua, Italy
5
Department of Medicine (DIMED), University of Padua, Via Gabelli 61, 35121 Padua, Italy
6
Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy
7
Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy
8
Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy
9
Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(13), 2885; https://doi.org/10.3390/nu15132885
Submission received: 30 May 2023 / Revised: 19 June 2023 / Accepted: 20 June 2023 / Published: 26 June 2023
(This article belongs to the Special Issue Diet, Microbioma and Gastrointestinal Cancers)
Browse Figures
Review Reports Versions Notes

Abstract

Esophageal adenocarcinoma (EAC) is the consequence of longstanding gastroesophageal reflux, which leads to inflammation and could cause Barrett’s esophagus (BE), the main risk factor for EAC development. The 5 year survival rate of EAC is poor since the diagnosis occurs at the late stage of the disease. To improve patient management, a better comprehension of the mechanism undergoing the evolution through to adenocarcinoma is needed. Within this scenario, the resident microbiome investigation was studied. This study aimed to explore the esophageal microbial profile in patients affected by non-dysplastic BE, low- and high-grade dysplastic BE, and EAC to identify parameters characterizing cancer progression and to develop a score suitable for clinical practice to stratify cancer risk. The microbiota was investigated through the 16S rRNA gene sequencing of esophageal biopsies. The microbial composition was evaluated at each different taxonomic level along the disease progression. To further investigate bacteria potentially associated with cancer development, non-dysplastic and dysplastic/cancer patients were compared. The presence of the six significant microbial features with multivariate analysis was used to develop a multiparametric score (Resident Esophageal Microbial Dysbiosis Test) to predict the risk of progression toward EAC. Finally, the diagnostic ability of the test and its discrimination threshold for its ability to identify dysplastic/cancer patients were demonstrated. Since EAC has been related to obesity, the relationship between these microbial parameters and patients’ diet/lifestyle habits was also investigated. Developing microbiome-based risk prediction models for esophageal adenocarcinoma onset could open new research avenues, demonstrating that the resident microbiome may be a valid cancer risk biomarker.
Keywords: microbiota; esophageal adenocarcinoma; diet microbiota; esophageal adenocarcinoma; diet

Share and Cite

MDPI and ACS Style

Zaramella, A.; Arcidiacono, D.; Nucci, D.; Fabris, F.; Benna, C.; Pucciarelli, S.; Fassan, M.; Fantin, A.; De Re, V.; Cannizzaro, R.; et al. Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations. Nutrients 2023, 15, 2885. https://doi.org/10.3390/nu15132885

AMA Style

Zaramella A, Arcidiacono D, Nucci D, Fabris F, Benna C, Pucciarelli S, Fassan M, Fantin A, De Re V, Cannizzaro R, et al. Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations. Nutrients. 2023; 15(13):2885. https://doi.org/10.3390/nu15132885

Chicago/Turabian Style

Zaramella, Alice, Diletta Arcidiacono, Daniele Nucci, Federico Fabris, Clara Benna, Salvatore Pucciarelli, Matteo Fassan, Alberto Fantin, Vallì De Re, Renato Cannizzaro, and et al. 2023. "Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations" Nutrients 15, no. 13: 2885. https://doi.org/10.3390/nu15132885

APA Style

Zaramella, A., Arcidiacono, D., Nucci, D., Fabris, F., Benna, C., Pucciarelli, S., Fassan, M., Fantin, A., De Re, V., Cannizzaro, R., & Realdon, S. (2023). Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett’s Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations. Nutrients, 15(13), 2885. https://doi.org/10.3390/nu15132885

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop