High-Fiber Diet and Crohn’s Disease: Systematic Review and Meta-Analysis

Round 1

Reviewer 1 Report

Dear authors an interesting subject and a interesting work.

Was it possible in some of the selected trials to indentify the type of fiber, soluble vs insoluble ?

Could you please improve the presentation of the table 3 and the figure 2 ?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

-        -   “indeterminate colitis (IC)” or unclassified IBD (IBD-U)?

 

-          - “indeterminate colitis (IC), the latter being the least frequent, accounting for 7-10% of IBD cases worldwide. Specifically, CD is the most common, accounting for 25-30% of IBD cases, with UC accounting for 20%”

 

20 + 30 + 10 = 60% -> what about the remaining 40%!?

 

-          - Use always upper case for western and eastern

 

-          - Use oxford comma in the whole text

 

-          - Define the abbreviations the first time they appear (for example, “F. prausnitzii”)

 

-          - Write the abbreviations of the authors that performed the studies’ evaluation instead of XXX

 

-          - Why did you choose the random effects in the meta-analysis?

 

-          - Graph of Figure 2 in wrong: in fact, the squares intersect the vertical line of the “0” values, despite the confidence intervals don’t intersect the 0 value. In addition, write what is the outcome

 

-          - Were CD patients excluded from the studies if they were affected by stenosing phenotype?

Moderate revision is needed.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Thank you for the corrections

It is improved

Author Response

Thank you very much for giving us the opportunity to improve the manuscript.