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Article

Glucosinolates Extracts from Brassica juncea Ameliorate HFD-Induced Non-Alcoholic Steatohepatitis

by
Ming-Jen Sheu
1,†,
Mei-Chen Yeh
2,†,
Ming-Chang Tsai
3,4,5,
Chi-Chih Wang
3,4,5,
Yen-Ling Chang
3,
Chau-Jong Wang
6,7,* and
Hui-Pei Huang
7,8,*
1
Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, No. 901, Zhonghua Rd. Yongkang Dist., Tainan City 71004, Taiwan
2
Division of Metabolism and Endocrinology, Department of Internal Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan
3
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
4
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
5
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
6
Department of Health Industry Technology Management, Chung Shan Medical University, Taichung 402, Taiwan
7
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
8
Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40242, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2023, 15(16), 3497; https://doi.org/10.3390/nu15163497
Submission received: 16 May 2023 / Revised: 26 July 2023 / Accepted: 3 August 2023 / Published: 8 August 2023
(This article belongs to the Special Issue The Impact of Probiotics/Prebiotics and Functional Foods in Human Health)
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is mainly characterized by excessive fat accumulation in the liver. It spans a spectrum of diseases from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Brassica juncea is rich in glucosinolates and has been proven to possess many potential pharmacological properties, including hypoglycemic, anti-oxidation, anti-inflammatory, and anti-carcinogenic activities. This study aims to investigate whether whole-plant Brassica juncea (WBJ) and its glucosinolates extracts (BGE) have hepatoprotective effects against a high-fat diet (HFD)-induced NAFLD and further explore the mechanism underlying this process in vivo and in vitro. WBJ treatment significantly reduced body fat, dyslipidemia, hepatic steatosis, liver injury, and inflammation; WBJ treatment also reversed the antioxidant enzyme activity to attenuate oxidative stress in HFD-fed rat liver. Moreover, WBJ and BGE enhanced the activation of AMPK to reduce SREBPs, fatty acid synthase, and HMG-CoA reductase but increased the expression of CPT-I and PPARα to improve hepatic steatosis. In addition, WBJ and BGE could ameliorate NAFLD by inhibiting TNF-α and NF-κB. Based on the above results, this study demonstrates that WBJ and BGE ameliorate HFD-induced hepatic steatosis and liver injury. Therefore, these treatments could represent an unprecedented hope toward improved strategies for NAFLD.
Keywords: non-alcoholic fatty liver disease (NAFLD); Brassica juncea; glucosinolates; high-fat diet (HFD); AMPK non-alcoholic fatty liver disease (NAFLD); Brassica juncea; glucosinolates; high-fat diet (HFD); AMPK

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MDPI and ACS Style

Sheu, M.-J.; Yeh, M.-C.; Tsai, M.-C.; Wang, C.-C.; Chang, Y.-L.; Wang, C.-J.; Huang, H.-P. Glucosinolates Extracts from Brassica juncea Ameliorate HFD-Induced Non-Alcoholic Steatohepatitis. Nutrients 2023, 15, 3497. https://doi.org/10.3390/nu15163497

AMA Style

Sheu M-J, Yeh M-C, Tsai M-C, Wang C-C, Chang Y-L, Wang C-J, Huang H-P. Glucosinolates Extracts from Brassica juncea Ameliorate HFD-Induced Non-Alcoholic Steatohepatitis. Nutrients. 2023; 15(16):3497. https://doi.org/10.3390/nu15163497

Chicago/Turabian Style

Sheu, Ming-Jen, Mei-Chen Yeh, Ming-Chang Tsai, Chi-Chih Wang, Yen-Ling Chang, Chau-Jong Wang, and Hui-Pei Huang. 2023. "Glucosinolates Extracts from Brassica juncea Ameliorate HFD-Induced Non-Alcoholic Steatohepatitis" Nutrients 15, no. 16: 3497. https://doi.org/10.3390/nu15163497

APA Style

Sheu, M.-J., Yeh, M.-C., Tsai, M.-C., Wang, C.-C., Chang, Y.-L., Wang, C.-J., & Huang, H.-P. (2023). Glucosinolates Extracts from Brassica juncea Ameliorate HFD-Induced Non-Alcoholic Steatohepatitis. Nutrients, 15(16), 3497. https://doi.org/10.3390/nu15163497

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