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Nutrients
Volume 15
Issue 16
10.3390/nu15163578
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Review

Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms

by
Michał Wiciński
1,
Jakub Erdmann
1,
Agnieszka Nowacka
2,*,
Oskar Kuźmiński
1,
Klaudia Michalak
1,
Kacper Janowski
1,
Jakub Ohla
3,
Adrian Biernaciak
1,
Monika Szambelan
1 and
Jan Zabrzyński
3
1
Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
2
Department of Neurosurgery, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
3
Department of Orthopaedics and Traumatology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-090 Bydgoszcz, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(16), 3578; https://doi.org/10.3390/nu15163578
Submission received: 14 July 2023 / Revised: 4 August 2023 / Accepted: 9 August 2023 / Published: 14 August 2023
(This article belongs to the Section Phytochemicals and Human Health)
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Abstract

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins (SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial cellular pathways and are regulated by many factors, such as chemicals, environmental stress, and phytochemicals. Several in vitro and in vivo studies have presented their involvement in anti-inflammatory, antioxidant, and antiapoptotic processes. Recent findings imply that phytochemicals such as resveratrol, curcumin, quercetin, fisetin, berberine, and kaempferol may regulate the activity of sirtuins. Resveratrol mainly activates SIRT1 and indirectly activates AMPK. Curcumin influences mainly SIRT1 and SIRT3, but its activity is broad, and many pathways in different cells are affected. Quercetin mainly modulates SIRT1, which triggers antioxidant and antiapoptotic responses. Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes. Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways. Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction. This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.
Keywords: sirtuins; phytochemical; resveratrol; curcumin; quercetin; fisetin; berberine; kaempferol sirtuins; phytochemical; resveratrol; curcumin; quercetin; fisetin; berberine; kaempferol

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MDPI and ACS Style

Wiciński, M.; Erdmann, J.; Nowacka, A.; Kuźmiński, O.; Michalak, K.; Janowski, K.; Ohla, J.; Biernaciak, A.; Szambelan, M.; Zabrzyński, J. Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms. Nutrients 2023, 15, 3578. https://doi.org/10.3390/nu15163578

AMA Style

Wiciński M, Erdmann J, Nowacka A, Kuźmiński O, Michalak K, Janowski K, Ohla J, Biernaciak A, Szambelan M, Zabrzyński J. Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms. Nutrients. 2023; 15(16):3578. https://doi.org/10.3390/nu15163578

Chicago/Turabian Style

Wiciński, Michał, Jakub Erdmann, Agnieszka Nowacka, Oskar Kuźmiński, Klaudia Michalak, Kacper Janowski, Jakub Ohla, Adrian Biernaciak, Monika Szambelan, and Jan Zabrzyński. 2023. "Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms" Nutrients 15, no. 16: 3578. https://doi.org/10.3390/nu15163578

APA Style

Wiciński, M., Erdmann, J., Nowacka, A., Kuźmiński, O., Michalak, K., Janowski, K., Ohla, J., Biernaciak, A., Szambelan, M., & Zabrzyński, J. (2023). Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms. Nutrients, 15(16), 3578. https://doi.org/10.3390/nu15163578

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