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Volume 15
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10.3390/nu15173857
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Review

Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review

by
Anna Olejnik
1,2,
Justyna Gornowicz-Porowska
3,*,
Dorota Jenerowicz
4,
Adriana Polańska
4,
Małgorzata Dobrzyńska
5,
Juliusz Przysławski
5,
Anna Sansone
6 and
Carla Ferreri
6,*
1
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland
2
Centre for Advanced Technology, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 10, 61-614 Poznań, Poland
3
Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Rokietnicka 3, 60-806 Poznań, Poland
4
Department of Dermatology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-356 Poznań, Poland
5
Department of Bromatology, Poznan University of Medical Sciences, Rokietnica 3, 60-806 Poznań, Poland
6
Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale Delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, Italy
*
Authors to whom correspondence should be addressed.
Nutrients 2023, 15(17), 3857; https://doi.org/10.3390/nu15173857
Submission received: 6 August 2023 / Revised: 26 August 2023 / Accepted: 1 September 2023 / Published: 4 September 2023
(This article belongs to the Section Nutritional Immunology)
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Abstract

Recently, the prevalence of atopic dermatitis has increased drastically, especially in urban populations. This multifactorial skin disease is caused by complex interactions between various factors including genetics, environment, lifestyle, and diet. In eczema, apart from using an elimination diet, the adequate content of fatty acids from foods (saturated, monounsaturated, and polyunsaturated fatty acids) plays an important role as an immunomodulatory agent. Different aspects regarding atopic dermatitis include connections between lipid metabolism in atopic dermatitis, with the importance of the MUFA levels, as well as of the omega-6/omega-3 balance that affects the formation of long-chain (C20 eicosanoic and C22 docosaenoic) fatty acids and bioactive lipids from them (such as prostaglandins). Impair/repair of the functioning of epidermal barrier is influenced by these fatty acid levels. The purpose of this review is to drive attention to membrane fatty acid composition and its involvement as the target of fatty acid supplementation. The membrane-targeted strategy indicates the future direction for dermatological research regarding the use of nutritional synergies, in particular using red blood cell fatty acid profiles as a tool for checking the effects of supplementations to reach the target and influence the inflammatory/anti-inflammatory balance of lipid mediators. This knowledge gives the opportunity to develop personalized strategies to create a healthy balance by nutrition with an anti-inflammatory outcome in skin disorders.
Keywords: atopic eczema; membrane remodeling; diet in skin diseases; n-3 PUFA; n-6 PUFA; membrane fatty acid profile atopic eczema; membrane remodeling; diet in skin diseases; n-3 PUFA; n-6 PUFA; membrane fatty acid profile

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MDPI and ACS Style

Olejnik, A.; Gornowicz-Porowska, J.; Jenerowicz, D.; Polańska, A.; Dobrzyńska, M.; Przysławski, J.; Sansone, A.; Ferreri, C. Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review. Nutrients 2023, 15, 3857. https://doi.org/10.3390/nu15173857

AMA Style

Olejnik A, Gornowicz-Porowska J, Jenerowicz D, Polańska A, Dobrzyńska M, Przysławski J, Sansone A, Ferreri C. Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review. Nutrients. 2023; 15(17):3857. https://doi.org/10.3390/nu15173857

Chicago/Turabian Style

Olejnik, Anna, Justyna Gornowicz-Porowska, Dorota Jenerowicz, Adriana Polańska, Małgorzata Dobrzyńska, Juliusz Przysławski, Anna Sansone, and Carla Ferreri. 2023. "Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review" Nutrients 15, no. 17: 3857. https://doi.org/10.3390/nu15173857

APA Style

Olejnik, A., Gornowicz-Porowska, J., Jenerowicz, D., Polańska, A., Dobrzyńska, M., Przysławski, J., Sansone, A., & Ferreri, C. (2023). Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review. Nutrients, 15(17), 3857. https://doi.org/10.3390/nu15173857

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