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Nutrients
Volume 15
Issue 19
10.3390/nu15194111
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Article

The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls

by
Bernadette Leser
1,
Nina Dalkner
2,*,
Adelina Tmava-Berisha
2,
Frederike T. Fellendorf
2,
Human-Friedrich Unterrainer
3,
Tatjana Stross
2,
Alexander Maget
2,
Martina Platzer
2,
Susanne A. Bengesser
2,
Alfred Häussl
2,
Ina Zwigl
2,
Armin Birner
2,
Robert Queissner
2,
Katharina Stix
2,
Linda Wels
2,
Elena M. D. Schönthaler
2,
Melanie Lenger
2,
Andreas R. Schwerdtfeger
1,
Sieglinde Zelzer
4,
Markus Herrmann
4 and
Eva Z. Reininghaus
2add Show full author list remove Hide full author list
1
Department of Psychology, University of Graz, 8010 Graz, Austria
2
Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria
3
Faculty of Psychotherapy Science, Sigmund Freud University, 1020 Vienna, Austria
4
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(19), 4111; https://doi.org/10.3390/nu15194111
Submission received: 18 August 2023 / Revised: 13 September 2023 / Accepted: 21 September 2023 / Published: 22 September 2023
(This article belongs to the Section Micronutrients and Human Health)
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Abstract

Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains “attention”, “memory”, or “executive function” in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study’s cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment.
Keywords: bipolar disorder; vitamin D; functional vitamin D deficiency; 25(OH)D; 24,25(OH)2D; VMR bipolar disorder; vitamin D; functional vitamin D deficiency; 25(OH)D; 24,25(OH)2D; VMR
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MDPI and ACS Style

Leser, B.; Dalkner, N.; Tmava-Berisha, A.; Fellendorf, F.T.; Unterrainer, H.-F.; Stross, T.; Maget, A.; Platzer, M.; Bengesser, S.A.; Häussl, A.; et al. The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls. Nutrients 2023, 15, 4111. https://doi.org/10.3390/nu15194111

AMA Style

Leser B, Dalkner N, Tmava-Berisha A, Fellendorf FT, Unterrainer H-F, Stross T, Maget A, Platzer M, Bengesser SA, Häussl A, et al. The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls. Nutrients. 2023; 15(19):4111. https://doi.org/10.3390/nu15194111

Chicago/Turabian Style

Leser, Bernadette, Nina Dalkner, Adelina Tmava-Berisha, Frederike T. Fellendorf, Human-Friedrich Unterrainer, Tatjana Stross, Alexander Maget, Martina Platzer, Susanne A. Bengesser, Alfred Häussl, and et al. 2023. "The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls" Nutrients 15, no. 19: 4111. https://doi.org/10.3390/nu15194111

APA Style

Leser, B., Dalkner, N., Tmava-Berisha, A., Fellendorf, F. T., Unterrainer, H.-F., Stross, T., Maget, A., Platzer, M., Bengesser, S. A., Häussl, A., Zwigl, I., Birner, A., Queissner, R., Stix, K., Wels, L., Schönthaler, E. M. D., Lenger, M., Schwerdtfeger, A. R., Zelzer, S., ... Reininghaus, E. Z. (2023). The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls. Nutrients, 15(19), 4111. https://doi.org/10.3390/nu15194111

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