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Nutrients
Volume 15
Issue 20
10.3390/nu15204372
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Article

Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway

by
Yu Jin Hwang
1,
Hye-Jeong Hwang
1,2,
Hyunseo Go
1,
NaYeong Park
1 and
Kyung-A Hwang
1,*
1
Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun 55365, Republic of Korea
2
Department of Food and Biotechnology, Korea University, Sejong City 30019, Republic of Korea
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(20), 4372; https://doi.org/10.3390/nu15204372
Submission received: 24 August 2023 / Revised: 28 September 2023 / Accepted: 30 September 2023 / Published: 16 October 2023
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
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Abstract

Sword bean (SB) contains various phytochemicals, such as flavonoids, tannins, saponins, and terpenoids. Although the evaluation of its potential functions, including antioxidant, anti-obesity, anti-inflammatory, liver protection, and antiangiogenic activities, has been widely reported, research on their use in osteoporosis prevention is insufficient. Furthermore, while various studies are conducted on SB, research on sword bean pods (SBP) is not yet active, and little is known about it. Therefore, this study investigated the effects of promoting osteoblast differentiation of MC3T3-E1 cells using SB and SBP extracts and their mechanisms. We show that SBP extracts increase osteoblast proliferation, mineralization-activated alkaline phosphatase (ALP), and collagen synthesis activities. Additionally, treatment with SBP extract increased the expression of markers related to osteoblast differentiation, such as ALP, SPARC, RUNX2, COL-I, BMP2, OCN, and OPN. It was confirmed that SBP induces differentiation by activating the BMP2/SMAD/RUNX2 pathway. We also show that SBP is more effective than SB, and SBP may be useful in assimilating bone minerals and preventing osteoporosis.
Keywords: sword bean pods; MC3T3-E1 cells; osteoblast; BMP2/SMAD/RUNX2 pathway sword bean pods; MC3T3-E1 cells; osteoblast; BMP2/SMAD/RUNX2 pathway

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MDPI and ACS Style

Hwang, Y.J.; Hwang, H.-J.; Go, H.; Park, N.; Hwang, K.-A. Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway. Nutrients 2023, 15, 4372. https://doi.org/10.3390/nu15204372

AMA Style

Hwang YJ, Hwang H-J, Go H, Park N, Hwang K-A. Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway. Nutrients. 2023; 15(20):4372. https://doi.org/10.3390/nu15204372

Chicago/Turabian Style

Hwang, Yu Jin, Hye-Jeong Hwang, Hyunseo Go, NaYeong Park, and Kyung-A Hwang. 2023. "Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway" Nutrients 15, no. 20: 4372. https://doi.org/10.3390/nu15204372

APA Style

Hwang, Y. J., Hwang, H.-J., Go, H., Park, N., & Hwang, K.-A. (2023). Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway. Nutrients, 15(20), 4372. https://doi.org/10.3390/nu15204372

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