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Nutrients
Volume 16
Issue 10
10.3390/nu16101514
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Review
Peer-Review Record

Effects of Saponins on Lipid Metabolism: The Gut–Liver Axis Plays a Key Role

Nutrients 2024, 16(10), 1514; https://doi.org/10.3390/nu16101514
by Shixi Cao 1, Mengqi Liu 1, Yao Han 1, Shouren Li 1, Xiaoyan Zhu 1,2,3, Defeng Li 1,2,3, Yinghua Shi 1,2,3,* and Boshuai Liu 1,2,3,*
Reviewer 1:
Cristiane Aguiar
Reviewer 2: Anonymous
Nutrients 2024, 16(10), 1514; https://doi.org/10.3390/nu16101514
Submission received: 7 April 2024 / Revised: 27 April 2024 / Accepted: 7 May 2024 / Published: 17 May 2024
(This article belongs to the Special Issue Anti-inflammatory and Anti-obesity Properties of Food Bioactive Components)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The review addresses a relevant topic for clinical medicine and health improvement, by showing natural alternatives for improving metabolic changes associated with diseases such as obesity. Therefore, I will make considerations to improve the review. 

1 - Why the authors chose to focus on saponins? The polyphenols are also natural compounds with many actions on the gut-liver axis.

2 - Page 5, line 145: change the citation Na RAe Shin to Shin et al., as in the references section.

3 - Does saponin inhibit pancreatic lipase activity in a similar way to Orlistat?

4 - Figure 5 The therm saponins are spelled wrong, it is spoanins. Please correct.

5 - Review the text as there is no space between the end of a sentence and the beginning of another sentence, or between the end and the reference number.

6 - Rewrite the first three lines of the conclusion (357,358,359), as they are meaningless

 

 

 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

ABSTRACT. Since you have not exceeded the limit of words in the abstract, additional results that obtained in your revision work can and should be included.

INTRODUCTION. Line 37. Besides saponins, could you provide additional examples of natural bioactive ingredients?

SOURCES OF SAPONINS. Lines 56-57. The term ‘non-food sources’ is not clear to me in this context. Why, for instance, are alfalfa and ginseng considered ‘non-food sources’?

SOURCES OF SAPONINS. Please, revise that scientific names of species are written correctly and in italics (in the main text and in Figures, not only in this section but throughout the whole manuscript).

SAPONINS ACTIVITIES. A table summarizing the revised studies is strongly recommended, compilating the effects, the responsible molecule, the experimental model, etc.

CONCLUSIONS AND OUTLOOK. Although current limitations are mentioned, future perspectives should be described more explicitly.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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