Next Article in Journal
Assessing Feeding Difficulties in Children Presenting with Non-IgE-Mediated Gastrointestinal Food Allergies—A Commonly Reported Problem
Previous Article in Journal
Vitamin D and Risk of Incident Type 2 Diabetes in Older Adults: An Updated Systematic Review and Meta-Analysis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 16
Issue 11
10.3390/nu16111562
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish

by
Ruiya Yi
1,†,
Bo Yang
1,†,
Hongjie Zhu
1,
Yu Sun
1,
Hailan Wu
1,
Zhihao Wang
1,
Yongbo Lu
1,
Ya-Wen He
2,* and
Jing Tian
1,*
1
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi’an 710069, China
2
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Development Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2024, 16(11), 1562; https://doi.org/10.3390/nu16111562
Submission received: 8 March 2024 / Revised: 13 April 2024 / Accepted: 14 May 2024 / Published: 22 May 2024
(This article belongs to the Section Nutritional Immunology)
Browse Figures
Review Reports Versions Notes

Abstract

The imbalance of gut microbiota is an important factor leading to inflammatory bowel disease (IBD). Diffusible signal factor (DSF) is a novel quorum-sensing signal that regulates bacterial growth, metabolism, pathogenicity, and host immune response. This study aimed to explore the therapeutic effect and underlying mechanisms of DSF in a zebrafish colitis model induced by sodium dextran sulfate (DSS). The results showed that intake of DSF can significantly improve intestinal symptoms in the zebrafish colitis model, including ameliorating the shortening of the intestine, reducing the increase in the goblet cell number, and restoring intestinal pathological damage. DSF inhibited the upregulation of inflammation-related genes and promoted the expression of claudin1 and occludin1 to protect the tightness of intestinal tissue. The gut microbiome analysis demonstrated that DSF treatment helped the gut microbiota of the zebrafish colitis model recover to normal at the phylum and genus levels, especially in terms of pathogenic bacteria; DSF treatment downregulated the relative abundance of Aeromonas hydrophila and Staphylococcus aureus, and it was confirmed in microbiological experiments that DSF could effectively inhibit the colonization and infection of these two pathogens in the intestine. This study suggests that DSF can alleviate colitis by inhibiting the proliferation of intestinal pathogens and inflammatory responses in the intestine. Therefore, DSF has the potential to become a dietary supplement that assists in the antibiotic and nutritional treatment of IBD.
Keywords: diffusible signal factor (DSF); quorum-sensing signal; inflammatory bowel disease (IBD); zebrafish model; gut microbiota diffusible signal factor (DSF); quorum-sensing signal; inflammatory bowel disease (IBD); zebrafish model; gut microbiota

Share and Cite

MDPI and ACS Style

Yi, R.; Yang, B.; Zhu, H.; Sun, Y.; Wu, H.; Wang, Z.; Lu, Y.; He, Y.-W.; Tian, J. Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish. Nutrients 2024, 16, 1562. https://doi.org/10.3390/nu16111562

AMA Style

Yi R, Yang B, Zhu H, Sun Y, Wu H, Wang Z, Lu Y, He Y-W, Tian J. Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish. Nutrients. 2024; 16(11):1562. https://doi.org/10.3390/nu16111562

Chicago/Turabian Style

Yi, Ruiya, Bo Yang, Hongjie Zhu, Yu Sun, Hailan Wu, Zhihao Wang, Yongbo Lu, Ya-Wen He, and Jing Tian. 2024. "Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish" Nutrients 16, no. 11: 1562. https://doi.org/10.3390/nu16111562

APA Style

Yi, R., Yang, B., Zhu, H., Sun, Y., Wu, H., Wang, Z., Lu, Y., He, Y.-W., & Tian, J. (2024). Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish. Nutrients, 16(11), 1562. https://doi.org/10.3390/nu16111562

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop