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Article

Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women

by
Yoshinori Kubo
1,2,*,
Hideoki Fukuoka
3,
Kumiko Shoji
1,
Chisato Mori
4,5,
Kenichi Sakurai
6,
Masazumi Nishikawa
7,
Kyoichi Oshida
8,
Yuichiro Yamashiro
9 and
Terue Kawabata
1
1
Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan
2
Division of Anatomy and Cell Biology, Department of Anatomy, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu 520-2192, Shiga, Japan
3
Department of Perinatal Mesenchymal Stem Cell Research, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Fukushima, Japan
4
Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Chiba, Japan
5
Department of Sustainable Health Science, Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Chiba, Japan
6
Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Chiba, Japan
7
Department of Food Management, School of Food, Agricultural and Environmental Sciences, Miyagi University, 2-2-1 Hatadate, Taihaku-ku, Sendai 982-0215, Miyagi, Japan
8
Faculty of Beauty & Wellness, Professional University of Beauty & Wellness, 3-9-3 Ushikubo, Tsuzuki-ku, Yokohama 224-0012, Kanagawa, Japan
9
Probiotics Research Laboratory, Graduate School of Medicine, Juntendo University, 2-9-8-3F, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(11), 1765; https://doi.org/10.3390/nu16111765
Submission received: 21 April 2024 / Revised: 24 May 2024 / Accepted: 26 May 2024 / Published: 4 June 2024
(This article belongs to the Special Issue Early Maternal Nutrition and Its Impact: Unraveling the Short- and Long-Term Health Consequences)
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Abstract

One-carbon metabolism (OCM) is a complex and interconnected network that undergoes drastic changes during pregnancy. In this study, we investigated the longitudinal distribution of OCM-related metabolites in maternal and cord blood and explored their relationships. Additionally, we conducted cross-sectional analyses to examine the interrelationships among these metabolites. This study included 146 healthy pregnant women who participated in the Chiba Study of Mother and Child Health. Maternal blood samples were collected during early pregnancy, late pregnancy, and delivery, along with cord blood samples. We analyzed 18 OCM-related metabolites in serum using stable isotope dilution liquid chromatography/tandem mass spectrometry. We found that serum S-adenosylmethionine (SAM) concentrations in maternal blood remained stable throughout pregnancy. Conversely, S-adenosylhomocysteine (SAH) concentrations increased, and the total homocysteine/total cysteine ratio significantly increased with advancing gestational age. The betaine/dimethylglycine ratio was negatively correlated with total homocysteine in maternal blood for all sampling periods, and this correlation strengthened with advances in gestational age. Most OCM-related metabolites measured in this study showed significant positive correlations between maternal blood at delivery and cord blood. These findings suggest that maternal OCM status may impact fetal development and indicate the need for comprehensive and longitudinal evaluations of OCM during pregnancy.
Keywords: one-carbon metabolism; 5-methyltetrahydrofolate; betaine; methionine; homocysteine; S-adenosylmethionine; S-adenosylhomocysteine; transsulfuration pathway; cysteine; pregnant woman one-carbon metabolism; 5-methyltetrahydrofolate; betaine; methionine; homocysteine; S-adenosylmethionine; S-adenosylhomocysteine; transsulfuration pathway; cysteine; pregnant woman
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MDPI and ACS Style

Kubo, Y.; Fukuoka, H.; Shoji, K.; Mori, C.; Sakurai, K.; Nishikawa, M.; Oshida, K.; Yamashiro, Y.; Kawabata, T. Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women. Nutrients 2024, 16, 1765. https://doi.org/10.3390/nu16111765

AMA Style

Kubo Y, Fukuoka H, Shoji K, Mori C, Sakurai K, Nishikawa M, Oshida K, Yamashiro Y, Kawabata T. Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women. Nutrients. 2024; 16(11):1765. https://doi.org/10.3390/nu16111765

Chicago/Turabian Style

Kubo, Yoshinori, Hideoki Fukuoka, Kumiko Shoji, Chisato Mori, Kenichi Sakurai, Masazumi Nishikawa, Kyoichi Oshida, Yuichiro Yamashiro, and Terue Kawabata. 2024. "Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women" Nutrients 16, no. 11: 1765. https://doi.org/10.3390/nu16111765

APA Style

Kubo, Y., Fukuoka, H., Shoji, K., Mori, C., Sakurai, K., Nishikawa, M., Oshida, K., Yamashiro, Y., & Kawabata, T. (2024). Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women. Nutrients, 16(11), 1765. https://doi.org/10.3390/nu16111765

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