The paper by Cesak et al. 2023 [1], titled ‘Carnosine and Beta-Alanine Supplementa-tion in Human Medicine: Narrative Review and Critical Assessment’, thoroughly re-views the importance of carnosine in human health. However, I was surprised to read that asparagus, green peas and white mushrooms were considered dietary sources of carnosine. To substantiate this claim, Cesak et al. cite the paper of Jones et al. 2011 [2]; however, these authors only reported the carnosine concentration of meat, fish and shellfish. In animals, carnosine’s imidazole ring has a well-recognised role in intracellular acid buffering [3,4]. In contrast, plants and fungi use very different intracellular systems to counter the challenges of low pH [5,6]. Even though the imidazole group of the amino acid histidine facilitates intracellular pH regulation in plants [5,7], in 2013 it was reported that histidine dipetides (which include carnosine) had never been detected in plants, fungi or other eukaryotes [8]. In light of this, could Cesak et al. provide a reference demonstrating the presence of carnosine in asparagus, green peas and white mushrooms?
Conflicts of Interest
The author has previously developed commercial food supplements containing beta-alanine for Alimentarius Ltd. These products were specifically formulated to increase muscle carnosine synthesis in humans.
References
- Cesak, O.; Vostalova, J.; Vidlar, A.; Bastlova, P.; Student, V., Jr. Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment. Nutrients 2023, 15, 1770. [Google Scholar] [CrossRef] [PubMed]
- Jones, G.; Smith, M.; Harris, R. Imidazole dipeptide content of dietary sources commonly consumed within the British diet. Proc. Nutr. Soc. 2011, 70, E363. [Google Scholar] [CrossRef]
- Harris, R.C.; Marlin, D.J.; Dunnett, M.; Snow, D.H.; Hultman, E. Muscle buffering capacity and dipeptide content in the thoroughbred horse, greyhound dog and man. Comp. Biochem. Physiol. A Comp. Physiol. 1990, 97, 249–251. [Google Scholar] [CrossRef] [PubMed]
- Tallon, M.J.; Harris, R.C.; Boobis, L.H.; Fallowfield, J.L.; Wise, J.A. The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders. J. Strength. Cond. Res. 2005, 19, 725–729. [Google Scholar] [CrossRef] [PubMed]
- Felle, H.H. pH regulation in anoxic plants. Ann. Bot. 2005, 96, 519–532. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Kane, P.M. Proton Transport and pH Control in Fungi. Adv. Exp. Med. Biol. 2016, 892, 33–68. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Ingle, R.A. Histidine biosynthesis. Arabidopsis. Book 2011, 9, e0141. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Boldyrev, A.A.; Aldini, G.; Derave, W. Physiology and pathophysiology of carnosine. Physiol. Rev. 2013, 93, 1803–1845. [Google Scholar] [CrossRef] [PubMed]
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