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Nutrients
Volume 16
Issue 16
10.3390/nu16162682
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Review

Experimental Models in Unraveling the Biological Mechanisms of Mushroom-Derived Bioactives against Aging- and Lifestyle-Related Diseases: A Review

by
Rajasekharan Sharika
1,2,
Kuljira Mongkolpobsin
1,2,
Panthakarn Rangsinth
3,
Mani Iyer Prasanth
4,5,
Sunita Nilkhet
1,2,
Paweena Pradniwat
1,6,
Tewin Tencomnao
4,5 and
Siriporn Chuchawankul
1,2,*
1
Immunomodulation of Natural Products Research Unit, Chulalongkorn University, Bangkok 10330, Thailand
2
Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
3
Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
4
Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok 10330, Thailand
5
Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
6
Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(16), 2682; https://doi.org/10.3390/nu16162682
Submission received: 14 July 2024 / Revised: 29 July 2024 / Accepted: 10 August 2024 / Published: 13 August 2024
(This article belongs to the Section Phytochemicals and Human Health)
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Abstract

Mushrooms have garnered considerable interest among researchers due to their immense nutritional and therapeutic properties. The presence of biologically active primary and secondary metabolites, which includes several micronutrients, including vitamins, essential minerals, and other dietary fibers, makes them an excellent functional food. Moreover, the dietary inclusion of mushrooms has been reported to reduce the incidence of aging- and lifestyle-related diseases, such as cancer, obesity, and stroke, as well as to provide overall health benefits by promoting immunomodulation, antioxidant activity, and enhancement of gut microbial flora. The multifunctional activities of several mushroom extracts have been evaluated by both in vitro and in vivo studies using cell lines along with invertebrate and vertebrate model systems to address human diseases and disorders at functional and molecular levels. Although each model has its own strengths as well as lacunas, various studies have generated a plethora of data regarding the regulating players that are modulated in order to provide various protective activities; hence, this review intends to compile and provide an overview of the plausible mechanism of action of mushroom-derived bioactives, which will be helpful in future medicinal explorations.
Keywords: mushrooms; bioactive compounds; in vitro; in vivo; molecular mechanism mushrooms; bioactive compounds; in vitro; in vivo; molecular mechanism

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MDPI and ACS Style

Sharika, R.; Mongkolpobsin, K.; Rangsinth, P.; Prasanth, M.I.; Nilkhet, S.; Pradniwat, P.; Tencomnao, T.; Chuchawankul, S. Experimental Models in Unraveling the Biological Mechanisms of Mushroom-Derived Bioactives against Aging- and Lifestyle-Related Diseases: A Review. Nutrients 2024, 16, 2682. https://doi.org/10.3390/nu16162682

AMA Style

Sharika R, Mongkolpobsin K, Rangsinth P, Prasanth MI, Nilkhet S, Pradniwat P, Tencomnao T, Chuchawankul S. Experimental Models in Unraveling the Biological Mechanisms of Mushroom-Derived Bioactives against Aging- and Lifestyle-Related Diseases: A Review. Nutrients. 2024; 16(16):2682. https://doi.org/10.3390/nu16162682

Chicago/Turabian Style

Sharika, Rajasekharan, Kuljira Mongkolpobsin, Panthakarn Rangsinth, Mani Iyer Prasanth, Sunita Nilkhet, Paweena Pradniwat, Tewin Tencomnao, and Siriporn Chuchawankul. 2024. "Experimental Models in Unraveling the Biological Mechanisms of Mushroom-Derived Bioactives against Aging- and Lifestyle-Related Diseases: A Review" Nutrients 16, no. 16: 2682. https://doi.org/10.3390/nu16162682

APA Style

Sharika, R., Mongkolpobsin, K., Rangsinth, P., Prasanth, M. I., Nilkhet, S., Pradniwat, P., Tencomnao, T., & Chuchawankul, S. (2024). Experimental Models in Unraveling the Biological Mechanisms of Mushroom-Derived Bioactives against Aging- and Lifestyle-Related Diseases: A Review. Nutrients, 16(16), 2682. https://doi.org/10.3390/nu16162682

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